CAJ | 학술논문

目的：探讨体外循环期间 Apelin-36、一氧化氮（NO）和肿瘤坏死因子-α（TNF-α）的变化和意义。方法：选择17例行直视下心脏手术患者，检测手术开始前（T0）、主动脉开放后即刻（T1）、主动脉开放后10 min（T2）、停机后即刻（T3）4个时间点动脉和静脉血浆中的 Apelin-36、NO 和 TNF-α浓度。结果：与术前（T0）比较，体外循环过程中动脉血 Apelin-36浓度在 T1、T2和 T3均升高（P ＜0．01或 P ＜0．05）；静脉血中 Apelin-36浓度在 T1和 T2时高于 T0（P ＜0．01）；动脉血 NO 浓度在 T1时、静脉血 NO 浓度在 T3时高于术前值（P ＜0．01或 P ＜0．05）；动脉血 TNF-α浓度在 T1和 T3以及静脉血 TNF-α浓度在T3高于术前（P ＜0．01）。结论：体外循环可诱导血浆中 Apelin-36、NO 和 TNF-α浓度的增加。
목적：탐토체외순배기간 Apelin-36、일양화담（NO）화종류배사인자-α（TNF-α）적변화화의의。방법：선택17례행직시하심장수술환자，검측수술개시전（T0）、주동맥개방후즉각（T1）、주동맥개방후10 min（T2）、정궤후즉각（T3）4개시간점동맥화정맥혈장중적 Apelin-36、NO 화 TNF-α농도。결과：여술전（T0）비교，체외순배과정중동맥혈 Apelin-36농도재 T1、T2화 T3균승고（P ＜0．01혹 P ＜0．05）；정맥혈중 Apelin-36농도재 T1화 T2시고우 T0（P ＜0．01）；동맥혈 NO 농도재 T1시、정맥혈 NO 농도재 T3시고우술전치（P ＜0．01혹 P ＜0．05）；동맥혈 TNF-α농도재 T1화 T3이급정맥혈 TNF-α농도재T3고우술전（P ＜0．01）。결론：체외순배가유도혈장중 Apelin-36、NO 화 TNF-α농도적증가。
Objective:To analyze the levels of plasma Apelin-36,nitric oxide (NO)and tumor necrosis factor-alpha (TNF-α) during cardiopulmonary bypass (CPB)in patients with cardiac surgery.Methods:Seventeen patients undergoing elective cardiac procedures with cardiopulmonary bypass were studied.The levels of arterial and venous plasma Apelin-36,NO and TNF-αwere measured by enzyme-linked immunosorbent assay at the following time points:before initiation of operation (T0),imme-diately after aortic declamping (T1),10 minutes after aortic declamping (T2)and the end of CPB (T3).Results:Compared with T0,Apelin-36 levels in arterial plasma elevated at three time points of T1,T2 and T3 (P <0.01 or P <0.05)and in ve-nous plasma elevated at two points of T1 and T2(P <0.01).The arterial plasma NO levels elevated at the time point of T1 and the venous NO levels elevated at the time point of T3(P <0.01 or P <0.05).The arterial plasma TNF-αlevels elevated at two time points of T1 and T3(P <0.01),and elevated in venous plasma at the time point of T3(P <0.01).Conclusions:CPB can increase the levels of plasma Apelin-36,NO and TNF-α.