CAJ | 학술논문

目的：分析银杏叶提取物治疗急性脑梗死的疗效及机制。方法：将44例急性脑梗死患者随机分为对照组（n＝21）和试验组（n＝23）。对照组应用阿司匹林及胞二磷胆碱进行治疗，试验组在对照组用药基础上加用银杏叶提取物口服治疗。在发病当天及治疗7 d、14 d 时，对两组患者进行神经功能缺损评分（采用改良爱丁堡—斯堪的那维亚评分，MESSS 评分）、日常生活能力评定（Barthel 指数），评价临床疗效。比较两组患者在发病当天及治疗7 d 时的血清超敏 C 反应蛋白（hs-CRP）、超氧化物歧化酶（SOD）、丙二醛（MDA）、内皮素-1（ET-1）、血栓素 B2（TXB2）水平的变化。结果：试验组与对照组治疗前后的 MESSS评分、Barthel 指数、血清 hs-CRP 水平差异无统计学意义（P ＞0．05）；但试验组临床疗效优于对照组，血清 SOD、MDA、ET-1、TXB2水平改善较对照组明显（P ＜0．05）。结论：银杏叶提取物联合阿司匹林及胞二磷胆碱治疗急性脑梗死的疗效较好，且无不良反应；这可能是药物提高了患者血清 SOD 及降低了 MDA、ET-1、TXB2水平的缘故。
목적：분석은행협제취물치료급성뇌경사적료효급궤제。방법：장44례급성뇌경사환자수궤분위대조조（n＝21）화시험조（n＝23）。대조조응용아사필림급포이린담감진행치료，시험조재대조조용약기출상가용은행협제취물구복치료。재발병당천급치료7 d、14 d 시，대량조환자진행신경공능결손평분（채용개량애정보—사감적나유아평분，MESSS 평분）、일상생활능력평정（Barthel 지수），평개림상료효。비교량조환자재발병당천급치료7 d 시적혈청초민 C 반응단백（hs-CRP）、초양화물기화매（SOD）、병이철（MDA）、내피소-1（ET-1）、혈전소 B2（TXB2）수평적변화。결과：시험조여대조조치료전후적 MESSS평분、Barthel 지수、혈청 hs-CRP 수평차이무통계학의의（P ＞0．05）；단시험조림상료효우우대조조，혈청 SOD、MDA、ET-1、TXB2수평개선교대조조명현（P ＜0．05）。결론：은행협제취물연합아사필림급포이린담감치료급성뇌경사적료효교호，차무불량반응；저가능시약물제고료환자혈청 SOD 급강저료 MDA、ET-1、TXB2수평적연고。
Objective:To analyse the effect and machanism of gingko biloba extract in the treatment of acute cerebral infarc-tion.Methods:Forty-four patients diagnosed as acute cerebral infarction were randomly divided into the control group (n=21) and the test group (n=23).Patients in the control group took aspirin,cytidine diphosphate choline and other conventional med-icines,while the patients in the test group received gingko biloba extract capsules combined with the medicine which used in the control group.The parameters measured during the study were MESSS score,Barthel Index,outcomes,and high-sensitivity C-reaction protein(hs-CRP),superoxide dismutase(SOD),malondialdehyde(MDA),endothelin-1(ET-1),thromboxane B2(TXB2) levels.Results:Compared with the control group,the MESSS score,Barthel Index and hs-CRP level in the test group were not improved(P >0.05),but the total clinical effects and the SOD,MDA,ET-1,TXB2 levels were obviously improved(P <0.05). Conclusions:Via increasing the SOD levels and decreasing the MDA,ET-1,TXB2 levels,the treatment of gingko biloba extract combined with aspirin and cytidine diphosphate choline in acute cerebral infarction is effective and safe.