CAJ | 학술논문

目的：探讨PET-CT中SUV值与肿瘤组织缺氧诱导因子（hypoxia inducible factor 1 alpha，HIF-1α）、AKT表达的相关性。方法对20例结直肠癌患者术前进行18F-FDG PET/CT检查，测定肿瘤平均标准摄取值（SUVmean）；手术切除标本进行病理检查，并应用免疫组织化学法检测肿瘤组织HIF-1α、AKT表达。分析SUVmean值与组织病理关系及与HIF-1α、AKT表达的相关性。结果20例结直肠癌患者均为高摄取，SUVmean值为（5.42±1.67）。SUVmean值与HIF-1α（r=0.595， P=0.006）、AKT（r=0.522，P=0.018）的表达均呈正相关。结论结直肠癌肿瘤组织中18F-FDG的浓聚与肿瘤组织的缺氧微环境有关。
목적：탐토PET-CT중SUV치여종류조직결양유도인자（hypoxia inducible factor 1 alpha，HIF-1α）、AKT표체적상관성。방법대20례결직장암환자술전진행18F-FDG PET/CT검사，측정종류평균표준섭취치（SUVmean）；수술절제표본진행병리검사，병응용면역조직화학법검측종류조직HIF-1α、AKT표체。분석SUVmean치여조직병리관계급여HIF-1α、AKT표체적상관성。결과20례결직장암환자균위고섭취，SUVmean치위（5.42±1.67）。SUVmean치여HIF-1α（r=0.595， P=0.006）、AKT（r=0.522，P=0.018）적표체균정정상관。결론결직장암종류조직중18F-FDG적농취여종류조직적결양미배경유관。
Objective To discuss the relationships between 18F-fluorodeoxyglucose (18F-FDG) uptake on PET/CT and the expression of hypoxia-inducible factor 1 alpha(HIF-1α) and AKT. Methods Twenty patients with colorectal cancer were imaged with 18F-FDG PET/CT before operation. The mean standard uptake value (SUVmean) were measured. Resected tumor samples were pathologic examined. The expression of Glut-1 and HIF-1αwas graded semiquantitatively by immunohistochemistry. The correlation of histopathology,Glut-1 and HIF-1αwith SUVmean were analyzed. Results The 18F-FDG uptakes of colorectal cancer were high and the SUVmean was (5.42±1.67). There were significantly correlations between SUVmean and expression of HIF-1α(r=0.595,P=0.006)and significantly correlations were found between SUVmean and expression of AKT(r=0.522,P=0.018) too. Conclusions 18F-FDG uptake correlates with expression of HIF-1αand AKT. FDG accumulation might be associated with the hypoxic microenvironment in tumors.