CAJ | 학술논문

目的：检测非小细胞肺癌（NSCLC）中抑癌基因TCF21蛋白的表达情况，探讨其与NSCLC各种临床病理特征间的关系。方法非选择性入组肺癌患者206例（观察组），其中鳞癌86例、腺癌及腺鳞癌99例、其它非小细胞肺癌21例；非肺癌组60例（对照组）；通过免疫组化（SP法）检测各种组织TCF21表达情况，分析其与患者各项临床指标及预后的关系。结果在观察组中TCF21阳性率明显低于对照组（P<0.05）。TCF21的低表达、与肿瘤的临床分期、分化程度、淋巴结转移及5年生存率密切相关（P<0.05）。结论 TCF21基因在NSCLC的发生、发展中起到重要作用，它的功能缺失可能是肺癌发生发展的主要机制之一；TCF21基因的表达情况可以作为NSCLC肿瘤转移和预后的指标。
목적：검측비소세포폐암（NSCLC）중억암기인TCF21단백적표체정황，탐토기여NSCLC각충림상병리특정간적관계。방법비선택성입조폐암환자206례（관찰조），기중린암86례、선암급선린암99례、기타비소세포폐암21례；비폐암조60례（대조조）；통과면역조화（SP법）검측각충조직TCF21표체정황，분석기여환자각항림상지표급예후적관계。결과재관찰조중TCF21양성솔명현저우대조조（P<0.05）。TCF21적저표체、여종류적림상분기、분화정도、림파결전이급5년생존솔밀절상관（P<0.05）。결론 TCF21기인재NSCLC적발생、발전중기도중요작용，타적공능결실가능시폐암발생발전적주요궤제지일；TCF21기인적표체정황가이작위NSCLC종류전이화예후적지표。
Purpose To investigate the expression of TCF21 protein,and observed their significance on clinical pathological characteristic in non-small cell lung carcinoma(NSCLC). Method Non selective into groups of 206 lung cancer patients,including 86 cases of squamous cell carcinoma,99 cases of adenocarcinoma oradenosquamous carcinoma,and 21 cases of non small cell lung cancer;using immunohistochemistry(SP method) to detect TCF21 expression in tissues. The association with clinicopathologic data and prognosis of NSCLC were analyzed. Results The lower expression of TCF21 was observed in NSCLC(P<0.05).The expression of TCF21 Was positively correlated with clinical stage,degree of tumor differentiation,lymph node metastasis and 5 years survival after operation(P<0.05). Conclusion TCF21 gene’s loss of function is one of the main mechanisms of lung cancer development. The expression of TCF21 can be regarded as indexes for tumor metastasis and prognosis in NSCLC.