CAJ | 학술논문

目的研究阿尔茨海默病(Alzheimer’s disease，AD)的弥散张量成像（DTI）改变，为AD的早期诊断提供依据。方法采用3.0T磁共振扫描仪对17例AD病人及17例对照组被试进行DTI检查。测量默认模式网络各种子点的FA值及脑白质纤维束感兴趣区的FA值。结果 AD组默认网络各脑区FA值较对照组均减低；联络系（双侧扣带束前、后部）、连合系（胼胝体膝部、体部及压部）、投射系（内囊前、后肢）的感兴趣区FA值较对照组均减低。结论阿尔茨海默病患者与正常老龄化组相比，弥散张量成像存在着特殊改变，能够为早期诊断阿尔茨海默病提供有效的功能影像学依据。
목적연구아이자해묵병(Alzheimer’s disease，AD)적미산장량성상（DTI）개변，위AD적조기진단제공의거。방법채용3.0T자공진소묘의대17례AD병인급17례대조조피시진행DTI검사。측량묵인모식망락각충자점적FA치급뇌백질섬유속감흥취구적FA치。결과 AD조묵인망락각뇌구FA치교대조조균감저；련락계（쌍측구대속전、후부）、련합계（변지체슬부、체부급압부）、투사계（내낭전、후지）적감흥취구FA치교대조조균감저。결론아이자해묵병환자여정상노령화조상비，미산장량성상존재착특수개변，능구위조기진단아이자해묵병제공유효적공능영상학의거。
Objective To explore the changes of FA values obtained by diffusion tensor imaging (DTI) study of patients suffered from Alzheimer’s disease.Methods 17 cases of AD and 17 cases of controls underwent DTI scan using Siemens Magnetom TrioTim 3.0T MR scanner. Fractional anisotropy (FA) values of ROI in white matter tracts and DMN regions were obtained, and FA values of the two groups were compared. Results FA values in different zones in DMN and various regions of interest which represent different types of fibers were lower in AD patients than that in the control group.Conclusion There were typical changes of DTI in AD patients, and it may help the early diagnosis of the disease.