浙江临床医学
浙江臨床醫學
절강림상의학
ZHEJIANG CLINICAL MEDICAL JOURNAL
2014年
11期
1725-1727
,共3页
何中倩%李晓东%田青%张升荣%陈宏洁
何中倩%李曉東%田青%張升榮%陳宏潔
하중천%리효동%전청%장승영%진굉길
高频振荡通气%常频通气%呼吸窘迫综合征%新生儿
高頻振盪通氣%常頻通氣%呼吸窘迫綜閤徵%新生兒
고빈진탕통기%상빈통기%호흡군박종합정%신생인
High frequency oscillatory ventilation%Convention menchanical ventilation%Respiratory distress syndrome%Neonates
目的:探讨高频振荡通气(HFOV)作为新生儿呼吸窘迫综合征(RDS)初始治疗的疗效及安全性。方法回顾性分析2010年1月至2013年6月住院治疗、需机械通气的RDS患儿50例,2011年11月前以常频机械通气的25例患儿作为CMV组,2011年11月后以高频振荡通气的25例患者患者作为HFOV组。结果机械通气1h后,两组患儿吸入氧浓度(FiO2)、平均气道压(MAP)、动脉血二氧化碳分压(PCO2)动脉血氧分压(PO2)均较0h有不同程度改善,且在1h及6hHFOV组较CMV组改善更明显,差异有统计学意义(P<0.05);机械通气24h后HFOV组的PO2、MAP与CMV组比较,差异无统计学意义(P>0.05),PCO2差异有统计学意义(P<0.05)。HFOV组患儿用氧时间与CMV组比较差异有统计学意义(P>0.05)。两组气漏、颅内出血、心力衰竭、DIC发生率差异无统计学意义(P>0.05)。两组患者休克发生率差异有统计学意义(P<0.05)。HFOV发生休克症状的病人增多,但积极处理后可以缓解。结论 HFOV能更好更快的改善RDS患儿的氧合功能,缩短用氧时间,但24h后的疗效与CMV组比较无差别,未缩短使用呼吸机的时间。未明显增加并发症的发生,休克积极处理后可以纠正。HFOV可以作为治疗新生儿呼吸窘迫综合征的又一选择。
目的:探討高頻振盪通氣(HFOV)作為新生兒呼吸窘迫綜閤徵(RDS)初始治療的療效及安全性。方法迴顧性分析2010年1月至2013年6月住院治療、需機械通氣的RDS患兒50例,2011年11月前以常頻機械通氣的25例患兒作為CMV組,2011年11月後以高頻振盪通氣的25例患者患者作為HFOV組。結果機械通氣1h後,兩組患兒吸入氧濃度(FiO2)、平均氣道壓(MAP)、動脈血二氧化碳分壓(PCO2)動脈血氧分壓(PO2)均較0h有不同程度改善,且在1h及6hHFOV組較CMV組改善更明顯,差異有統計學意義(P<0.05);機械通氣24h後HFOV組的PO2、MAP與CMV組比較,差異無統計學意義(P>0.05),PCO2差異有統計學意義(P<0.05)。HFOV組患兒用氧時間與CMV組比較差異有統計學意義(P>0.05)。兩組氣漏、顱內齣血、心力衰竭、DIC髮生率差異無統計學意義(P>0.05)。兩組患者休剋髮生率差異有統計學意義(P<0.05)。HFOV髮生休剋癥狀的病人增多,但積極處理後可以緩解。結論 HFOV能更好更快的改善RDS患兒的氧閤功能,縮短用氧時間,但24h後的療效與CMV組比較無差彆,未縮短使用呼吸機的時間。未明顯增加併髮癥的髮生,休剋積極處理後可以糾正。HFOV可以作為治療新生兒呼吸窘迫綜閤徵的又一選擇。
목적:탐토고빈진탕통기(HFOV)작위신생인호흡군박종합정(RDS)초시치료적료효급안전성。방법회고성분석2010년1월지2013년6월주원치료、수궤계통기적RDS환인50례,2011년11월전이상빈궤계통기적25례환인작위CMV조,2011년11월후이고빈진탕통기적25례환자환자작위HFOV조。결과궤계통기1h후,량조환인흡입양농도(FiO2)、평균기도압(MAP)、동맥혈이양화탄분압(PCO2)동맥혈양분압(PO2)균교0h유불동정도개선,차재1h급6hHFOV조교CMV조개선경명현,차이유통계학의의(P<0.05);궤계통기24h후HFOV조적PO2、MAP여CMV조비교,차이무통계학의의(P>0.05),PCO2차이유통계학의의(P<0.05)。HFOV조환인용양시간여CMV조비교차이유통계학의의(P>0.05)。량조기루、로내출혈、심력쇠갈、DIC발생솔차이무통계학의의(P>0.05)。량조환자휴극발생솔차이유통계학의의(P<0.05)。HFOV발생휴극증상적병인증다,단적겁처리후가이완해。결론 HFOV능경호경쾌적개선RDS환인적양합공능,축단용양시간,단24h후적료효여CMV조비교무차별,미축단사용호흡궤적시간。미명현증가병발증적발생,휴극적겁처리후가이규정。HFOV가이작위치료신생인호흡군박종합정적우일선택。
Objective To investigate efficacy and safety of high frequency oscillatory ventilation(HFOV) for neonatal respiratory distress syndrome( RDS). Methods A retrospective analysis is studied in 50 cases of newborns who need mechanical ventilation of RDS from January 2010 to June 2013 in our hospital. The infants who were born after November 2011 were research group(HFOV,25 cases). The infants who were born before November 2011 were control group(CMV,25cases). Results One hour after giving mechanical ventilation,there was an increase in the PO2,and decrease in PCO2,FiO2,MAP in both groups. There was more significant difference in these dates at one hour and six hour after giving mechanical ventilation in HFOV group(P<0.05).There was no difference in PO2、MAP and there was difference in PCO2(P<0.05)between two groups at 24 hour.But there was difference in high oxygen concentration exposure time between HFOV group and CMV group.(P>0.05). No significant differences were found in air leak,intracranial hemorrhage,heart failure,DIC between two groups(P>0.05). There was statistically significant in shock between groups(P<0.05). There were more infants occurred shock in HFOV group,but after actively treatment,they improved soon. Conclusions HFOV has a better pulmomary oxygenation and decreased time of high oxygen concentration exposure. There was no difference in the curative effect compared with CMV group after 24 hours .HFOV could not shorten the time of the use of ventilation. HFOV did not significantly increase the occurrence of complications. There were more infants who got shock in HFOV group,but after actively treatment,they improved soon. HFOV can serve as an alternative for the treatment of neonatal respiratory distress syndrome.