CAJ | 학술논문

目的：探讨归龙汤对糖尿病血管病变大鼠免疫的影响。方法：将80只大鼠随机分为空白对照组、模型对照组、西洛他唑组、归龙汤（低、中、高）剂量组，并造糖尿病血管病变大鼠模型。空白对照组和模型对照组的大鼠每日喂饲蒸馏水；西洛他唑组每日喂饲西洛他唑片1.67 mg／kg；归龙汤组予以不同剂量的归龙汤灌胃。用药56 d 后，牺牲实验大鼠，测定大鼠血清中血糖及免疫指标的水平，同时取大鼠主动脉弓下段2～3 cm 主动脉，在光镜下观察主动脉粥样硬化病变及其程度。结果：糖尿病血管病变大鼠的免疫指标中 IgM、IgA 和 C3升高，IgG 降低。低、中、高剂量的归龙汤均能使糖尿病血管病变大鼠的免疫指标恢复正常。结论：归龙汤能够有效调节糖尿病血管病变大鼠免疫失衡状态。
목적：탐토귀룡탕대당뇨병혈관병변대서면역적영향。방법：장80지대서수궤분위공백대조조、모형대조조、서락타서조、귀룡탕（저、중、고）제량조，병조당뇨병혈관병변대서모형。공백대조조화모형대조조적대서매일위사증류수；서락타서조매일위사서락타서편1.67 mg／kg；귀룡탕조여이불동제량적귀룡탕관위。용약56 d 후，희생실험대서，측정대서혈청중혈당급면역지표적수평，동시취대서주동맥궁하단2～3 cm 주동맥，재광경하관찰주동맥죽양경화병변급기정도。결과：당뇨병혈관병변대서적면역지표중 IgM、IgA 화 C3승고，IgG 강저。저、중、고제량적귀룡탕균능사당뇨병혈관병변대서적면역지표회복정상。결론：귀룡탕능구유효조절당뇨병혈관병변대서면역실형상태。
Objective:To investigate the effect of Guilong decoction on the immune mechanism of rats with diabetic angiopathy.Meth-ods:Eighty rats were randomly divided into blank control group,model control group,cilostazol group,Guilong (low,middle,high dose) group.Models of rats with diabetic angiopathy were made.Rats in the blank control group and the model control group were daily fed with distilled water.The cilostazol group daily fed rats with 1.67 mg/kg cilostazol;Guilong decoction group gave different doses of Guilong decoction.After 56 days,the experimental rats were killed,and the blood glucose and immune indices in serum of rats were detected.The atherosclerotic aortic lesions were observed under the microscope.Results:IgM,IgA and C3 immune indexes of diabetic angiopathy in rats were increased,IgG was decreased.The high,middle and low dose Guilong decoction could return the immune index in rats with diabet-ic angiopathy to normal.Conclusion:Guilong decoction can effectively regulate the immune imbalance of rats with diabetic angiopathy.