CAJ | 학술논문

干扰素刺激基因15蛋白（ISG15）是一种类泛素蛋白，可在干扰素刺激下由 isg15基因编码产生。其在序列、结构和功能上均与泛素类似，能够通过酶级联反应共价修饰靶蛋白。ISG15及其类泛素修饰系统参与免疫应答，是干扰素发挥抗病毒效应的重要途径。目前已证明 ISG15可针对多种病毒发挥抗病毒活性，包括逆转录酶病毒、大 DNA 病毒、正链 RNA 病毒和负链 RNA 病毒等。论文综合近年来的研究成果，对 ISG15及其类泛素修饰系统进行了简要介绍，并重点讨论了 ISG15的抗病毒活性及其机制。
간우소자격기인15단백（ISG15）시일충류범소단백，가재간우소자격하유 isg15기인편마산생。기재서렬、결구화공능상균여범소유사，능구통과매급련반응공개수식파단백。ISG15급기류범소수식계통삼여면역응답，시간우소발휘항병독효응적중요도경。목전이증명 ISG15가침대다충병독발휘항병독활성，포괄역전록매병독、대 DNA 병독、정련 RNA 병독화부련 RNA 병독등。논문종합근년래적연구성과，대 ISG15급기류범소수식계통진행료간요개소，병중점토론료 ISG15적항병독활성급기궤제。
Interferon-stimulated gene 15 (ISG15)is a kind of ubiquitin (Ub)-like protein,which is coded by isg 15 gene under interferon stimulation.It is similar to Ub in sequence,structure and function,which can covalently modify target protein by enzyme cascade.ISG15 and its Ub-like modification system participate in the immune response,which is an important pathway for the interferon exerting antiviral effect.It is demonstrated thatISG15 could play antiviral activity against various viruses,including retrovirus,large DNA virus,positive-strand virus and negative-strand virus,et al.In this paper,we synthesized the re-search achievements in recent years,introduced ISG15 and its Ub-like modification system briefly,and dis-cussed ISG15 antivirus activity as well as its mechanism in detail.