CAJ | 학술논문

目前临床所用控制流感病毒的药物和疫苗受到病毒耐药性、疫苗滞后性等诸多因素的限制，使能阻止病毒侵入宿主细胞的抑制剂成为当前研究的热点。唾液酸是流感病毒囊膜表面血凝素（HA）的受体，但研究表明唾液酸并不适合作为研制流感病毒侵入宿主细胞抑制剂的结构模型。研究发现流感病毒的HA 受体结合位点必须外露才能与宿主细胞受体结合，因此 HA 受体结合位点可以被宿主免疫系统监视，成为抗体潜在的靶向契合位点。随后发现的 HA 受体结合位点抗体能与 HA 受体结合位点的保守氨基酸残基结合，能有效阻止流感病毒感染宿主。因此，可用 HA 受体结合位点抗体作为流感病毒感染抑制剂的模型，研制流感病毒抑制剂。论文就流感病毒 HA 的分子结构和功能，HA 结合受体的机制，HA 受体结合位点抗体以及该类抗体对流感病毒的抑制效果进行了阐述，以期对以 HA 受体结合位点抗体为模型研制流感病毒感染抑制剂提供帮助。
목전림상소용공제류감병독적약물화역묘수도병독내약성、역묘체후성등제다인소적한제，사능조지병독침입숙주세포적억제제성위당전연구적열점。타액산시류감병독낭막표면혈응소（HA）적수체，단연구표명타액산병불괄합작위연제류감병독침입숙주세포억제제적결구모형。연구발현류감병독적HA 수체결합위점필수외로재능여숙주세포수체결합，인차 HA 수체결합위점가이피숙주면역계통감시，성위항체잠재적파향계합위점。수후발현적 HA 수체결합위점항체능여 HA 수체결합위점적보수안기산잔기결합，능유효조지류감병독감염숙주。인차，가용 HA 수체결합위점항체작위류감병독감염억제제적모형，연제류감병독억제제。논문취류감병독 HA 적분자결구화공능，HA 결합수체적궤제，HA 수체결합위점항체이급해류항체대류감병독적억제효과진행료천술，이기대이 HA 수체결합위점항체위모형연제류감병독감염억제제제공방조。
The anti-flu drugs and flu vaccines were restricted at some time in clinic.So the influenza virus entry inhibitor agents has become the focus of current research.Sialic acid is the receptor of HA,but using sialic acid as viral entry blockers has not been successful,it indicates that sialic acid may not be an ideal scaffold for influenza virus entry inhibitor agents.The receptor binding site of HA must be exposed for binding to host sialic acid receptors,so that the receptor binding site can be monitored by the host immune system,as the potential target binding sites for antibodies.Some antibodies can bind the highly conserved amino acids on the receptor binding site of HA,that inhibits virus infection to hosts.So the antibodies tar-geting binding receptor site of HA may be the new idea for human combat influenza virus.This paper re-viewed the molecular structure and function of the influenza virus HA,mechanism of HA binding the re-ceptors,described the inhibition effect of the antibody to influenza virus entry.in order to supply help for preparation of antibodies inhibiting HA receptor binding site and research influenza virus entry inhibitor.