CAJ | 학술논문

Mx蛋白是在脊椎动物机体细胞受病毒感染或诱生剂处理时由Ⅰ型干扰素诱导表达的一种抗病毒蛋白。Mx 蛋白具有良好的抗病毒能力，靶向许多 RNA 病毒，诸如流感病毒、水疱性口炎病毒、狂犬病毒等，对某些 DNA 病毒，例如乙型肝炎病毒也有一定的作用。近年来，基于鸡的 Mx 蛋白抗病毒作用及机制的相关研究逐渐增多，取得了一些进展。论文就近年来鸡 Mx 蛋白的抗病毒机制与分子生物学特点进行综述，针对鸡 Mx 蛋白在抗病毒与品种鸡抗病育种筛选等应用前景进行分析与探讨。
Mx단백시재척추동물궤체세포수병독감염혹유생제처리시유Ⅰ형간우소유도표체적일충항병독단백。Mx 단백구유량호적항병독능력，파향허다 RNA 병독，제여류감병독、수포성구염병독、광견병독등，대모사 DNA 병독，례여을형간염병독야유일정적작용。근년래，기우계적 Mx 단백항병독작용급궤제적상관연구축점증다，취득료일사진전。논문취근년래계 Mx 단백적항병독궤제여분자생물학특점진행종술，침대계 Mx 단백재항병독여품충계항병육충사선등응용전경진행분석여탐토。
Mx protein is an antiviral protein expressed in cells of vertebrates induced by type Ⅰ interferon (IFN)under virus infection or induced agent treatment.Mx protein has good antiviral ability,targeted many RNA viruses,such as the influenza virus,vesicular stomatitis virus,rabies virus and so on,and also has certain effects for some DNA virus,such as hepatitis B virus.In recent years,related researches accu-mulate based on antiviral effect and mechanism of chicken Mx protein,and obtain some progress.In this review,we discussed the antiviral mechanism and molecular biology characteristics of chicken Mx protein, analyzed the application prospect of the chicken Mx protein in antiviral effect and disease-resistant breeding selection in order to provide reference for research and application of chicken Mx protein.