CAJ | 학술논문

目的：了解2012年1月1日至2013年12月31日少数民族聚居的大理白族自治州第一人民医院手足口病患儿肠道病毒71型（EV71）的感染状况，为临床诊治提供参考。方法采集首诊手足口病1028例患儿的咽拭子标本，应用实时RT-PCR法检测标本中的EV71。结果1028例手足口病咽拭子样本中EV71的阳性病例数为274；阳性率为26.65%，2013年咽拭子样本EV71阳性检出率30.93%(150/485)高于2012年22.84％(124/543)，差异有统计学意义(P<O.05)；2012、2013年均以EV71感染为主，病毒流行株差异有统计学意义(P<0.01)。结论2012和2013年我院手足口病患儿EV71检出率分别为22.84%和30.93%是手足口病的主要致病病毒之一,2013年E V71感染的手足口病比例较2012年出现明显上升。E V71是大理白族地区手足口病的主要致病病毒，流行特征和病原学分析有助于手足口病的早期防控和治疗。
목적：료해2012년1월1일지2013년12월31일소수민족취거적대리백족자치주제일인민의원수족구병환인장도병독71형（EV71）적감염상황，위림상진치제공삼고。방법채집수진수족구병1028례환인적인식자표본，응용실시RT-PCR법검측표본중적EV71。결과1028례수족구병인식자양본중EV71적양성병례수위274；양성솔위26.65%，2013년인식자양본EV71양성검출솔30.93%(150/485)고우2012년22.84％(124/543)，차이유통계학의의(P<O.05)；2012、2013년균이EV71감염위주，병독류행주차이유통계학의의(P<0.01)。결론2012화2013년아원수족구병환인EV71검출솔분별위22.84%화30.93%시수족구병적주요치병병독지일,2013년E V71감염적수족구병비례교2012년출현명현상승。E V71시대리백족지구수족구병적주요치병병독，류행특정화병원학분석유조우수족구병적조기방공화치료。
Objective: Understanding the entervirus 71 (EV71) infection status of children with hand-foot -and -mouth disease from January 1, 2012 to December 31, 2013 in the First People's Hospital, Dali Bai Minority Autonomous Prefecture, and providing reference for clinical diagnosis and treatment.Methods: Colected the first Pharyngeal swab specimens on 1028 cases of children hand-foot -and -mouth disease, and then used real-time RT-PCR method to detect EV71 in the specimens.Results :the number of the positive cases of EV71 was 274 in the pharyngeal swab samples of 1028 cases of hand-foot- and- mouth disease, the rate was 26.65℅. 30.93℅ (150/485) in 2013, the rate was much higher than 22.84℅ (124/543) in 2012. The difference was statisticaly significant (P<0.05). Both 2012, 2013 was focus on the EV71 infection, the difference between virus epidemic strains was statisticaly significant (P<0.01) Conclusion : the EV71 detection rate on children with hand-foot -and -mouth disease were 22.84℅and 30.93℅ in 2012 and 2013, and became one of the main pathogenic virus of this disease. Obviously, the infection rate of EV71 in 2013 was much higher than it was in 2012. So, the study on the epidemic characteristics and etiology wil contribute to the early prevention and treatment of hand-foot –and- mouth disease.