上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
22期
24-26,33
,共4页
妊娠%依沙吖啶%米非司酮%引产
妊娠%依沙吖啶%米非司酮%引產
임신%의사아정%미비사동%인산
pregnancy%ethacridine%mifepristone%induction of labor
目的：观察米非司酮口服联合依沙吖啶羊膜腔内注射终止中期妊娠的效果。方法：选择孕16～27周自愿终止妊娠的健康孕妇276例，随机分为观察组140例和对照组136例。观察组于依沙吖啶羊膜腔内注射后0、12、24 h口服米非司酮50 mg，总量150 mg。对照组仅行依沙吖啶羊膜腔内注射引产。比较两组引产总产程、产后24 h出血量、胎盘胎膜残留率、宫颈裂伤及一次引产成功率。结果：观察组引产总产程短、产后24 h出血量少，胎盘胎膜残留率低，与对照组相比差异有统计学意义（P<0.01)。观察组和对照组的宫颈裂伤发生率分别为0%和1.47%，一次引产成功率分别为100%及97.8%，组间差异均无统计学意义（P>0.05)。结论：米非司酮口服联合依沙吖啶羊膜腔内注射终止中期妊娠是一种简单、安全、有效、快速的方法。
目的：觀察米非司酮口服聯閤依沙吖啶羊膜腔內註射終止中期妊娠的效果。方法：選擇孕16～27週自願終止妊娠的健康孕婦276例，隨機分為觀察組140例和對照組136例。觀察組于依沙吖啶羊膜腔內註射後0、12、24 h口服米非司酮50 mg，總量150 mg。對照組僅行依沙吖啶羊膜腔內註射引產。比較兩組引產總產程、產後24 h齣血量、胎盤胎膜殘留率、宮頸裂傷及一次引產成功率。結果：觀察組引產總產程短、產後24 h齣血量少，胎盤胎膜殘留率低，與對照組相比差異有統計學意義（P<0.01)。觀察組和對照組的宮頸裂傷髮生率分彆為0%和1.47%，一次引產成功率分彆為100%及97.8%，組間差異均無統計學意義（P>0.05)。結論：米非司酮口服聯閤依沙吖啶羊膜腔內註射終止中期妊娠是一種簡單、安全、有效、快速的方法。
목적：관찰미비사동구복연합의사아정양막강내주사종지중기임신적효과。방법：선택잉16～27주자원종지임신적건강잉부276례，수궤분위관찰조140례화대조조136례。관찰조우의사아정양막강내주사후0、12、24 h구복미비사동50 mg，총량150 mg。대조조부행의사아정양막강내주사인산。비교량조인산총산정、산후24 h출혈량、태반태막잔류솔、궁경렬상급일차인산성공솔。결과：관찰조인산총산정단、산후24 h출혈량소，태반태막잔류솔저，여대조조상비차이유통계학의의（P<0.01)。관찰조화대조조적궁경렬상발생솔분별위0%화1.47%，일차인산성공솔분별위100%급97.8%，조간차이균무통계학의의（P>0.05)。결론：미비사동구복연합의사아정양막강내주사종지중기임신시일충간단、안전、유효、쾌속적방법。
Objective:To observe the efifcacy of the intra-amniotic injection of mifepristone combined with ethacridine for the termination of the second trimester pregnancy. Methods:Two hundred and seventy-six women between the 16th and 27th weeks of gestation who voluntarily asked for a termination of the second trimester pregnancy were selected and randomly assigned into an observation group with 140 cases and a control group with 136 ones. The observe group after receiving an intra-amniotic injection administrated ethacridine orally of 50 mg mifepristone at 0, 12 and 24 hours and its total dose was 150 mg. The women in the control group only received 100 mg ethacridine by the intra-amniotic injection. The total birth process of the induction of labor, blood loss in 24 h after labor, retained placental tissue rate, cervical laceration and successful abortion rate were compared between two groups. Results:The total birth process of the induction of labor was shorten, blood loss in 24 h lose less and the retained placental tissue rate in the observe group was obviously less, and comparing with the control group, the difference had the statistical signiifcance (P<0.01). The incidence of the cervical laceration in the observe group and in the control group was 0 and 1.47%, respectively, and their successful abortion rates were 100%and 97.8%, respectively. The difference of two groups had no statistical signiifcance (P>0.05). Conclusion:The intra-amniotic injection of mifepristone combined with ethacridine for the termination of the second trimester pregnancy is a simple, safe, effective and fast method.
