河北医药
河北醫藥
하북의약
HEBEI MEDICAL JOURNAL
2014年
23期
3528-3530
,共3页
慢性神经病理性疼痛%头孢曲松钠%GLT-1%CCI
慢性神經病理性疼痛%頭孢麯鬆鈉%GLT-1%CCI
만성신경병이성동통%두포곡송납%GLT-1%CCI
chronic neuropathic pain%ceftriaxone%GLT-1%CCI
目的：观察β-内酰胺类抗生素头孢曲松钠（ Ceftriaxone，Cef）对慢性神经病理性痛过敏的影响。方法雄性SD大鼠60只，随机分为Sham组、CCI（坐骨神经结扎）组、Cef预防组、Cef治疗组，后2组设腹腔注射0．9％氯化钠溶液组作为对照，每组10只。于术后第1天、第3天、第5天、第7天、第9天、第11天和第14天测定热缩足潜伏期和机械缩足反射阈值。结果 CCI诱导大鼠产生了热和机械性痛敏，Cef预防组大鼠CCI侧后肢热缩足反射潜伏期于CCI后第5天、第7天，机械缩足反射阈值于术后第7天同NS对照组以及CCI组相比明显延长（ P ＜0．05）；Cef 治疗组大鼠CCI侧后肢热缩足反射潜伏期在术后第11天、第14天，机械缩足反射阈值于术后第14天同NS 对照组以及CCI组相比明显延长（ P ＜0．05）。结论 Cef对慢性神经病理性痛起到了预防和治疗作用。
目的：觀察β-內酰胺類抗生素頭孢麯鬆鈉（ Ceftriaxone，Cef）對慢性神經病理性痛過敏的影響。方法雄性SD大鼠60隻，隨機分為Sham組、CCI（坐骨神經結扎）組、Cef預防組、Cef治療組，後2組設腹腔註射0．9％氯化鈉溶液組作為對照，每組10隻。于術後第1天、第3天、第5天、第7天、第9天、第11天和第14天測定熱縮足潛伏期和機械縮足反射閾值。結果 CCI誘導大鼠產生瞭熱和機械性痛敏，Cef預防組大鼠CCI側後肢熱縮足反射潛伏期于CCI後第5天、第7天，機械縮足反射閾值于術後第7天同NS對照組以及CCI組相比明顯延長（ P ＜0．05）；Cef 治療組大鼠CCI側後肢熱縮足反射潛伏期在術後第11天、第14天，機械縮足反射閾值于術後第14天同NS 對照組以及CCI組相比明顯延長（ P ＜0．05）。結論 Cef對慢性神經病理性痛起到瞭預防和治療作用。
목적：관찰β-내선알류항생소두포곡송납（ Ceftriaxone，Cef）대만성신경병이성통과민적영향。방법웅성SD대서60지，수궤분위Sham조、CCI（좌골신경결찰）조、Cef예방조、Cef치료조，후2조설복강주사0．9％록화납용액조작위대조，매조10지。우술후제1천、제3천、제5천、제7천、제9천、제11천화제14천측정열축족잠복기화궤계축족반사역치。결과 CCI유도대서산생료열화궤계성통민，Cef예방조대서CCI측후지열축족반사잠복기우CCI후제5천、제7천，궤계축족반사역치우술후제7천동NS대조조이급CCI조상비명현연장（ P ＜0．05）；Cef 치료조대서CCI측후지열축족반사잠복기재술후제11천、제14천，궤계축족반사역치우술후제14천동NS 대조조이급CCI조상비명현연장（ P ＜0．05）。결론 Cef대만성신경병이성통기도료예방화치료작용。
Objective To observe the effects of ceftriaxone ( Cef) on chronic neuropathic pain after sciatic nerve ligation ( CCI) .Method s Sixty male Spague-Dawley rats were randomly divided into sham-operation group;CCI group;Cef prevention group;Cef treatment group, at the same time, the rats who were injected intraperitoneally with NS were used as control group,with 10 rats in each group.Thermal withdrawal latency and mechanical withdrawal threshold were measured at 1, 3,5,7, 9,11 and 14 days after operation.Resutl s The CCI induced thermal hyperalgesia and mechanical allodynia in rats.In Cef prevention group, the thermal withdrawal latency at 5, 7 days and mechanical withdrawal threshold in the hindpaw ipsilateral to CCI at 7 days after operation were obviously prolonged,as compared with those in NS control group and CCI group ( P <0.05).In Cef treatment group,the thermal withdrawal latency at 11,14 days after operation,and mechanical withdrawal threshold in the hindpaw ipsilateral to CCI at 14 days after operation were significantly prolonged,as compared with those in NS control group and CCI group( P <0.05).Conclusion Cef has preventive and therapeutic effects on chronic neuropathic pain.
