CAJ | 학술논문

目的：探讨血清糖类相关抗原19-9(CA19-9)对消化系统恶性梗阻性黄疸的临床诊断价值，为该类疾病的临床诊治提供参考。方法以本院2010年5月~2013年7月收治的168例梗阻性黄疸患者为研究对象，对各类梗阻患者血清中的CA19-9水平及临床诊断率进行统计分析。结果胆系结石和硬化性胆管炎致梗阻性黄疸患者治疗后血清CA19-9水平均显著低于治疗前，差异有统计学意义(P<0.01)；而胆管癌、胰腺癌、十二指肠壶腹癌和肝细胞癌致梗阻性黄疸患者治疗后血清CA19-9水平与治疗前比较，差异无统计学意义(P>0.05)。 CA19-9在恶性梗阻性黄疸的诊断中，对胆管癌和胰腺癌的诊断灵敏度、特异度、阳性预测值等较高。结论血清CA19-9对于区别梗阻性黄疸良恶性及诊断胆管癌和胰腺癌表现出较高的临床价值。
목적：탐토혈청당류상관항원19-9(CA19-9)대소화계통악성경조성황달적림상진단개치，위해류질병적림상진치제공삼고。방법이본원2010년5월~2013년7월수치적168례경조성황달환자위연구대상，대각류경조환자혈청중적CA19-9수평급림상진단솔진행통계분석。결과담계결석화경화성담관염치경조성황달환자치료후혈청CA19-9수평균현저저우치료전，차이유통계학의의(P<0.01)；이담관암、이선암、십이지장호복암화간세포암치경조성황달환자치료후혈청CA19-9수평여치료전비교，차이무통계학의의(P>0.05)。 CA19-9재악성경조성황달적진단중，대담관암화이선암적진단령민도、특이도、양성예측치등교고。결론혈청CA19-9대우구별경조성황달량악성급진단담관암화이선암표현출교고적림상개치。
Objective To investigate the clinical value of serum carbohydrate-associated antigen 19-9 (CA19-9) for the diagnosis of digestive malignant obstructive jaundice,expect to provide a reference for the diagnosis of the diseases. Methods 168 cases of patients with obstructive jaundice treated in our hospital from May 2010 to July 2013 were se-lected,the levels of CA19-9 and diagnosis rate of different patients with obstructive jaundice were analyzed. Results The serum CA19-9 of biliary stones and sclerosing cholangitis patients with obstructive jaundice after treatment were lower than those before treatment,the difference was significant (P<0.01);while the serum CA19-9 of bile duct,pancreas, duodenum pot abdominal cancer and hepatocellular carcinoma after treatment compared with before treatment,the dif-ference was not significant (P>0.05).CA19-9 had a high sensitivity,specificity,positive predictive value for cholangiocar-cinoma and pancreatic cancer. Conclusion CA19-9 has a definite clinical value for the diagnosis of benign jaundice and malignant jaundice,and benefit to the diagnosis of cholangiocarcinoma and pancreatic cancer.