CAJ | 학술논문

目的：调查研究精神分裂症人群戊型肝炎的感染状况。方法对1649例精神分裂症患者进行现况调查。收集患者血清，采用ELISA方法进行戊型肝炎病毒(HEV)-IgG以及HEV-IgM抗体的检测，采用Logistic回归方法分析抗体阳性率与性别、年龄、病程以及各生化指标之间的相关性。结果精神分裂症人群HEV-IgG抗体阳性率为33.54%。随着年龄的增加，IgG抗体阳性率逐渐升高，Logistic分析结果显示，以9~20岁年龄组为参照，>20~30岁、>30~40岁、>40~50岁以及>50岁组的HEV-IgG阳性率OR值(95%CI)分别为1.45(0.94，2.24)(P=0.096)、3.20(2.05，4.99)(P<0.001)、3.22(2.03，5.11)(P<0.001)和5.54(3.34，9.21)(P<0.001)。不同的性别、不同病程HEV-IgG阳性率差异无统计学意义(P>0.05)。以正常组为参照，谷氨酰转肽酶升高组OR值(95%CI)为1.87(1.12，3.12)(P=0.016)。IgM抗体阳性者13人，且均伴有IgG抗体阳性。结论精神分裂症人群HEV感染率较高，应采取相应措施对该人群进行HEV预防，从而从源头上降低整个人群HEV的发病率。
목적：조사연구정신분렬증인군무형간염적감염상황。방법대1649례정신분렬증환자진행현황조사。수집환자혈청，채용ELISA방법진행무형간염병독(HEV)-IgG이급HEV-IgM항체적검측，채용Logistic회귀방법분석항체양성솔여성별、년령、병정이급각생화지표지간적상관성。결과정신분렬증인군HEV-IgG항체양성솔위33.54%。수착년령적증가，IgG항체양성솔축점승고，Logistic분석결과현시，이9~20세년령조위삼조，>20~30세、>30~40세、>40~50세이급>50세조적HEV-IgG양성솔OR치(95%CI)분별위1.45(0.94，2.24)(P=0.096)、3.20(2.05，4.99)(P<0.001)、3.22(2.03，5.11)(P<0.001)화5.54(3.34，9.21)(P<0.001)。불동적성별、불동병정HEV-IgG양성솔차이무통계학의의(P>0.05)。이정상조위삼조，곡안선전태매승고조OR치(95%CI)위1.87(1.12，3.12)(P=0.016)。IgM항체양성자13인，차균반유IgG항체양성。결론정신분렬증인군HEV감염솔교고，응채취상응조시대해인군진행HEV예방，종이종원두상강저정개인군HEV적발병솔。
Objective To investigate the infection status of hepatitis E virus (HEV) in schizophrenia patients. Methods In this cross-sectional study, 1649 schizophrenia patients were recruited. The serum samples were collected. Anti-HEV IgG and IgM were tested by ELISA method. Logistic regression analysis was used to calculate the relationship between gender, age, the duration of schizophrenia, lab test and the positivity of the antibodies. Results 33.54% of the total subjects were anti-HEV IgG positive. The multivariable adjusted ORs (95% CI) of risk of the positivity of anti-HEV IgG were 1.45 (0.94, 2.24) (P=0.096), 3.20 (2.05, 4.99) (P<0.001), 3.22 (2.03, 5.11) (P<0.001) and 5.54 (3.34, 9.21) (P< 0.001) for the group of the age >20-30,>30-40, >40-50 and>50, compared to the group of the age 9-20. There was no significant difference between gender, duration and the positivity of anti-HEV IgG (P>0.05). Compared to nor-mal group, the positivity of anti-HEV IgG was significantly higher in the higher GGT group (OR = 1.87, 95%CI(1.12,3.12), P= 0.016). IgG and IgM were coexisted in 13 individuals. Conclusion This study indicates that the infection status in schizophrenia is serious. Effective prevention strategies are required in future for reducing HEV transmission in schizophrenic patients, in order to reduce the incidence of whole human beings.