CAJ | 학술논문

目的：比较埃索美拉唑与奥美拉唑治疗胃溃疡的临床效果。方法选取本院2012年12月~2014年1月收治的胃溃疡患者138例,随机分为治疗组和对照组,每组69例。治疗组采用埃索美拉唑治疗,对照组采用奥美拉唑治疗。观察比较两组患者的症状积分、临床疗效及Hp根除率。结果治疗后,治疗组患者的症状积分显著低于对照组(t=5.3204,P=0.0000)；治疗组总有效率显著高于对照组,差异有统计学意义(χ2=12.6374,P=0.0004)；治疗组Hp根除率显著高于对照组,差异有统计学意义(χ2=11.4701,P=0.0007)。结论埃索美拉唑治疗胃溃疡,临床效果显著,是治疗胃溃疡的理想选择之一。
목적：비교애색미랍서여오미랍서치료위궤양적림상효과。방법선취본원2012년12월~2014년1월수치적위궤양환자138례,수궤분위치료조화대조조,매조69례。치료조채용애색미랍서치료,대조조채용오미랍서치료。관찰비교량조환자적증상적분、림상료효급Hp근제솔。결과치료후,치료조환자적증상적분현저저우대조조(t=5.3204,P=0.0000)；치료조총유효솔현저고우대조조,차이유통계학의의(χ2=12.6374,P=0.0004)；치료조Hp근제솔현저고우대조조,차이유통계학의의(χ2=11.4701,P=0.0007)。결론애색미랍서치료위궤양,림상효과현저,시치료위궤양적이상선택지일。
Objective To compare the clinical effect of esomeprazole and omeprazole in treatment of gastric ulcer. Methods 138 cases of patients with gastric ulcer in our hospital from December 2012 to January 2014 were selected and randomly divided into treatment group and control group,69 cases in each group.Esomeprazole was given to the treatment group,and omeprazole was given to the control group.The clinical treatment of symptom score,the total effec-tive rate and the rate of Hp eradication of the two groups were observed and compared. Results The clinical treatment of symptom score of the treatment group was significantly lower than that of the control group,the difference was signifi-cant (t=5.3204,P=0.0000).The total effective rate and the rate of Hp eradication of the treatment group was higher than that of the control group respectively,the difference was significant (χ2=12.6374,P=0.0004;χ2=11.4701,P=0.0007). Con-clusion The clinical efficacy of esomeprazole in treatment of gastric ulcer is significant,it is one of the ideal choice for clinical treatment of gastric ulcer.