CAJ | 학술논문

目的：通过分析中枢神经系统白血病患儿的临床特点与其发生和预后的关系，为cnsl的预防和治疗提供参考。方法分析12例cnsl患儿的临床表现、分型及预后。结果我科收治的急性白血病患儿75例中，出现中枢神经系统浸润12例，发生率16%。其中急性淋巴细胞白血病（all）10例（18.97%），急性髓细胞白血病(aMl)1例（6.2%）。10例all中4例为B-all,6例t-all，t-all合并cnsl发生率（31.5%）高于B-all（10.1%）。cnsl常伴随骨髓复发，预后差，死亡率高。结论 cnsl是影响儿童急性白血病患儿长期生存率的重要因素，其预防和治疗已成为儿童al治疗的关键之一。
목적：통과분석중추신경계통백혈병환인적림상특점여기발생화예후적관계，위cnsl적예방화치료제공삼고。방법분석12례cnsl환인적림상표현、분형급예후。결과아과수치적급성백혈병환인75례중，출현중추신경계통침윤12례，발생솔16%。기중급성림파세포백혈병（all）10례（18.97%），급성수세포백혈병(aMl)1례（6.2%）。10례all중4례위B-all,6례t-all，t-all합병cnsl발생솔（31.5%）고우B-all（10.1%）。cnsl상반수골수복발，예후차，사망솔고。결론 cnsl시영향인동급성백혈병환인장기생존솔적중요인소，기예방화치료이성위인동al치료적관건지일。
ABSTRAC: Objectiveto analyze the correlation between the clinical features and the occurrence and prognosis of cnsl, and to provide references for the prevention and treatment of cnsl.Methods the clinical manifestations, typing and prognosis of 12 cases of children with cnsl were analyzed.Results there were 75 cases of acute leukemia in children admitted to our department. the incidence of cnsl was 16% (12 cases), of which patients with all was 10 cases (18.97%) and patient with aMl was 1 case (6.2%). in 10 cases of all, there were 4 cases of B-all and 6 cases of t-all. the incidence rate of t-all (31.5%)complicated with cnsl was higher than that of B-all complicated with cnsl (10.1%). also, cnsl was often accompanied by bone marrow relapse, with poor prognosis and high death rate.Conclusions cnsl is an important factor affecting the long-term survival rate of children with al. Prevention and treatment to cnsl has become one of the key points to treat with al in children.