CAJ | 학술논문

目的：探讨头颅核磁共振成像(MRI)对新生儿重度高胆红素血症的诊断价值。方法选取本院收治的102例重度高胆红素血症足月新生儿作为研究对象,所有患儿均行头颅MRI检查,分析、总结其MRI图像特点及临床应用价值。结果通过对102例患儿的MRI图像进行分析,T1加权图像(T1WI)显示苍白球对称性高信号者66例(64.7%),余下36例(35.3%)患儿则未见苍白球信号改变,所有患儿的扩散加权成像(DWI)均未见异常信号。苍白球T1WI高信号者的血清总胆红素(TSB)、直接胆红素(CB)、间接胆红素(UCB)、总胆红素与白蛋白(ALB)比值(B/A)等指标显著高于苍白球信号正常者,差异有统计学意义(P<0.05)。两组胆红素水平的比较,显示苍白球信号改变与胆红素水平有一定联系,差异有统计学意义(P<0.05)。结论重度高胆红素血症患儿的头颅MRI表现具有特征性,对于该病症的早期鉴别、诊断以及预后评估具有重要意义。
목적：탐토두로핵자공진성상(MRI)대신생인중도고담홍소혈증적진단개치。방법선취본원수치적102례중도고담홍소혈증족월신생인작위연구대상,소유환인균행두로MRI검사,분석、총결기MRI도상특점급림상응용개치。결과통과대102례환인적MRI도상진행분석,T1가권도상(T1WI)현시창백구대칭성고신호자66례(64.7%),여하36례(35.3%)환인칙미견창백구신호개변,소유환인적확산가권성상(DWI)균미견이상신호。창백구T1WI고신호자적혈청총담홍소(TSB)、직접담홍소(CB)、간접담홍소(UCB)、총담홍소여백단백(ALB)비치(B/A)등지표현저고우창백구신호정상자,차이유통계학의의(P<0.05)。량조담홍소수평적비교,현시창백구신호개변여담홍소수평유일정련계,차이유통계학의의(P<0.05)。결론중도고담홍소혈증환인적두로MRI표현구유특정성,대우해병증적조기감별、진단이급예후평고구유중요의의。
Objective To explore the diagnostic value of brain MRI in neonates with severe hyperbilirubinemia. Meth-ods 102 cases of neonates with severe hyperbilirubinemia were selected as research object.All patients were examined with brain MRI,the MRI image characteristics and clinical applications were analyzed and summarized. Results Through the analysis of MRI images of 102 cases,T1-weighted images (T1WI) displayed high signal symmetry globus pallidus were 66 cases(64.7%),the remaining 36 cases(35.3%) of children were not seen in the globus pallidus signal changes.Diffusion-weighted imaging (DWI) of all children showed that there was no abnormal signal.Serum total bilirubin (TSB),direct bilirubin(CB) indirect bilirubin(UCB),total bilirubin and albumin(ALB) ratio(B/A) and other indicators in the group which globus pallidus T1WI signal changed were significantly higher than the others which globus pallidus signal didn’t change,with statistical difference(P<0.05).Seen from the comparison of the two groups of children with bilirubin levels,changes in globus pallidus signal had some contact with bilirubin levels,of which the difference was statistically significant (P<0.05). Conclusion Brain MRI findings in children with severe hyperbilirubinemia has significant features,which has im-portant implications for the early identification,diagnosis and prognosis of the disease.