CAJ | 학술논문

目的：研究依那普利叶酸片治疗H型高血压合并颈动脉粥样硬化的效果。方法将212例H型高血压(Hcy>10μmol/L)合并颈动脉粥样硬化(颈动脉彩超显示有动脉内膜中层增厚或有颈动脉粥样硬化斑块)的患者随机分为试验组和对照组，试验组110例，对照组102例，分别给予依那普利叶酸片和依那普利片，均连续治疗12个月，比较两组治疗前后血压控制水平、血Hcy水平、颈动脉内膜中层厚度。结果两组治疗前后的血压值比较差异均有统计学意义(P<0.05)，两组治疗后的血压值比较差异无统计学意义(P>0.05)。试验组治疗前后的血Hcy水平比较差异有统计学意义(P<0.01)，对照组治疗前后的血Hcy水平比较差异无统计学意义(P>0.05)。试验组治疗前后的颈动脉内膜中层厚度比较差异有统计学意义(P<0.05)，对照组治疗前后的颈动脉内膜中层厚度比较差异无统计学意义(P>0.05)。结论依那普利叶酸片治疗H型高血压效果显著，可以降低血压水平及血Hcy水平，并可控制动脉粥样硬化的进展，从而降低心血管疾病的发生率。
목적：연구의나보리협산편치료H형고혈압합병경동맥죽양경화적효과。방법장212례H형고혈압(Hcy>10μmol/L)합병경동맥죽양경화(경동맥채초현시유동맥내막중층증후혹유경동맥죽양경화반괴)적환자수궤분위시험조화대조조，시험조110례，대조조102례，분별급여의나보리협산편화의나보리편，균련속치료12개월，비교량조치료전후혈압공제수평、혈Hcy수평、경동맥내막중층후도。결과량조치료전후적혈압치비교차이균유통계학의의(P<0.05)，량조치료후적혈압치비교차이무통계학의의(P>0.05)。시험조치료전후적혈Hcy수평비교차이유통계학의의(P<0.01)，대조조치료전후적혈Hcy수평비교차이무통계학의의(P>0.05)。시험조치료전후적경동맥내막중층후도비교차이유통계학의의(P<0.05)，대조조치료전후적경동맥내막중층후도비교차이무통계학의의(P>0.05)。결론의나보리협산편치료H형고혈압효과현저，가이강저혈압수평급혈Hcy수평，병가공제동맥죽양경화적진전，종이강저심혈관질병적발생솔。
Objective To investigate the effect of enalapril folic acid tablets in the treatment of H-hypertension com-bined with carotid atherosclerosis. Methods 212 patients with H-hypertension (Hcy>10μmol/L)and carotid atheroscle-rosis(carotid artery intima-media ultrasound showed a thickening or carotid atherosclerotic plaques)were selected and randomly divided into experimental group(110 patients)and control group(102 patients).Enalapril folic acid tablets were used in experimental group,enalapril tablets were applied in control group,all patitents were treated for 12 months of continuous therapy.The level of blood pressure,blood Hcy level,carotid intima-media thickness in two groups before and after treatment was compared respectively. Results The blood pressure of two groups before and after treatment was compared respectively,with statistical difference(P<0.05).After treatment,the blood pressure of two groups was compared, with no statistical difference(P>0.05).There was statistical difference of blood Hcy before and after treatment in experi-mental group (P<0.01),but that of control group had no statistical difference (P>0.05).There was statistical difference of carotid intima-media thickness before and after treatment in experimental group (P<0.05),but that of control group had no statistical difference(P>0.05). Conclusion Enalapril folic acid tablets in the treatment of H-hypertension has signifi-cant effect,can decrease the level of blood pressure and Hcy,and also control the progress of atherosclerosis,thereby re-duce the incidence rate of cardiovascular disease.