中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
31期
75-77
,共3页
消化性溃疡%消化道出血%注射用奥美拉唑钠%疗效%安全性
消化性潰瘍%消化道齣血%註射用奧美拉唑鈉%療效%安全性
소화성궤양%소화도출혈%주사용오미랍서납%료효%안전성
Peptic ulcer%Gastrointestinal bleeding%Omeprazole sodium for injection%Efficacy%Safety
目的：探讨注射用奥美拉唑钠治疗消化性溃疡合并上消化道出血的效果和安全性。方法将60例消化性溃疡合并上消化道出血患者按照1：1随机分为对照组与观察组，两组患者均给予抗休克、输血及输液等基础治疗，对照组在基础治疗上采用法莫替丁注射液进行治疗，观察组在基础治疗上采用注射用奥美拉唑钠进行治疗，对比两组的临床治疗效果、治疗前后空腹胃液pH值及不良反应发生情况。结果对照组总有效率为66.67%，显著低于观察组的93.33%(P<0.05)。两组治疗前后空腹胃液pH值比较差异有统计学意义(P<0.05)，且观察组治疗后空腹胃液pH值显著高于对照组(P<0.05)。对照组不良反应发生率为20.00%，显著高于观察组的6.67%(P<0.05)。结论新型质子泵抑制剂注射用奥美拉唑钠应用于消化性溃疡合并上消化道出血的疗效显著，安全性高，值得推广应用。
目的：探討註射用奧美拉唑鈉治療消化性潰瘍閤併上消化道齣血的效果和安全性。方法將60例消化性潰瘍閤併上消化道齣血患者按照1：1隨機分為對照組與觀察組，兩組患者均給予抗休剋、輸血及輸液等基礎治療，對照組在基礎治療上採用法莫替丁註射液進行治療，觀察組在基礎治療上採用註射用奧美拉唑鈉進行治療，對比兩組的臨床治療效果、治療前後空腹胃液pH值及不良反應髮生情況。結果對照組總有效率為66.67%，顯著低于觀察組的93.33%(P<0.05)。兩組治療前後空腹胃液pH值比較差異有統計學意義(P<0.05)，且觀察組治療後空腹胃液pH值顯著高于對照組(P<0.05)。對照組不良反應髮生率為20.00%，顯著高于觀察組的6.67%(P<0.05)。結論新型質子泵抑製劑註射用奧美拉唑鈉應用于消化性潰瘍閤併上消化道齣血的療效顯著，安全性高，值得推廣應用。
목적：탐토주사용오미랍서납치료소화성궤양합병상소화도출혈적효과화안전성。방법장60례소화성궤양합병상소화도출혈환자안조1：1수궤분위대조조여관찰조，량조환자균급여항휴극、수혈급수액등기출치료，대조조재기출치료상채용법막체정주사액진행치료，관찰조재기출치료상채용주사용오미랍서납진행치료，대비량조적림상치료효과、치료전후공복위액pH치급불량반응발생정황。결과대조조총유효솔위66.67%，현저저우관찰조적93.33%(P<0.05)。량조치료전후공복위액pH치비교차이유통계학의의(P<0.05)，차관찰조치료후공복위액pH치현저고우대조조(P<0.05)。대조조불량반응발생솔위20.00%，현저고우관찰조적6.67%(P<0.05)。결론신형질자빙억제제주사용오미랍서납응용우소화성궤양합병상소화도출혈적료효현저，안전성고，치득추엄응용。
Objective To investigate the efficacy and safety of omeprazole sodium for injection in the treatment of pep-tic ulcer complicated with upper gastrointestinal hemorrhage. Methods 60 patients with peptic ulcer complicated with upper gastrointestinal hemorrhage were randomly divided into control group and observation group according to the ra-tio of 1:1.Two groups of patients were given the basic treatment of anti shock,blood transfusion and infusion.Famotidine injection was used in control group based on the treatment above while omeprazole sodium for injection was applied in observation group on the basis of above treatment.Clinical curative effect,pH value of gastric juice before and after treatment and the incidence rate of adverse reaction in two groups was compared respectively. Results Total effective rate in control group was 66.67%,significantly lower than that in observation group (93.33%)(P<0.05).The pH value of gastric juice in two groups before and after treatment was compared respectively,with statistical difference(P<0.05).After treatment,pH value of gastric juice in observation group was significantly higher than that in control group (P<0.05).The incidence rate of adverse reaction in control group was 20.00%,significantly higher than that in observation group (6.67%)(P<0.05). Conclusion Omeprazole sodium for injection(new proton pump inhibitor)applied in peptic ulcer com-plicated with upper gastrointestinal bleeding has significant effect and high safety,which is worthy of promotion and ap-plication.
