CAJ | 학술논문

目的：分析血清胰蛋白酶原-2、CA199、CA50、CA242在胰腺癌诊断中的应用价值。方法选取解放军北京军区总医院、石景山医院诊为胰腺癌未经治疗的患者25例,随机选取体检中心健康体检者35例为对照组。入组者均留取血清标本,采用ELISA法半定量检测血清胰蛋白酶原-2、CA199、CA50、CA242的含量。结果血清胰蛋白酶原-2、CA199、CA50、CA242诊断胰腺癌ROC曲线下面积均>0.5(P<0.05),其中胰蛋白酶原-2曲线下面积最大,其次为CA199,CA50与CA242相仿。结论4种血清肿瘤标志物胰蛋白酶原-2、CA199、CA50、CA242对胰腺癌均有一定的诊断价值,但因各自具有局限性,均非单一理想诊断胰腺癌的肿瘤标志物。
목적：분석혈청이단백매원-2、CA199、CA50、CA242재이선암진단중적응용개치。방법선취해방군북경군구총의원、석경산의원진위이선암미경치료적환자25례,수궤선취체검중심건강체검자35례위대조조。입조자균류취혈청표본,채용ELISA법반정량검측혈청이단백매원-2、CA199、CA50、CA242적함량。결과혈청이단백매원-2、CA199、CA50、CA242진단이선암ROC곡선하면적균>0.5(P<0.05),기중이단백매원-2곡선하면적최대,기차위CA199,CA50여CA242상방。결론4충혈청종류표지물이단백매원-2、CA199、CA50、CA242대이선암균유일정적진단개치,단인각자구유국한성,균비단일이상진단이선암적종류표지물。
Objective To evaluate the diagnostic value of serum trypsinogen-2,CA199,CA50,CA242 in pancreatic can-cer. Methods 25 cases of patients diagnosed pancreatic cancer,but not carried out treatment in General Hospital of Chinese PLA Beijing Command and Beijing Shijingshan Hospital were collected,35 cases of healthy people were select-ed as control group,serum samples were collected from all patients,the level of serum trypsinogen-2,CA199,CA50 and CA242 was detected by ELISA. Results The area of ROC curve of serum trypsinogen-2,CA199,CA50 and CA242 ex-ceeded 0.5 (P<0.05),of which,the area of ROC curve of serum trypsinogen-2 was largest,then was the CA199,CA50 and CA242 were similar. Conclusion There is certain diagnostic value of serum trypsinogen-2,CA199,CA50 and CA242 in pancreatic cancer.But all of them have linmitations,is not a single ideal diagnosis of pancreatic cancer tumor markers.