CAJ | 학술논문

目的：探讨COPD急性加重患者（ AECOPD）血清降钙素原（ PCT）、C反应蛋白（ CRP）水平变化及其与FEV1％预计值的相关性。方法测定40例COPD患者（急性加重期20例、稳定期20例）、正常对照组的20例健康受试者血清PCT、CRP水平，并分析COPD急性加重期PCT、CRP与第1秒用力呼气流量占预计值百分比（ FEV1％）的相关性。结果 COPD急性加重患者PCT、CRP水平高于稳定期患者和对照组，差异有统计学意义（P＜0．05）。 COPD稳定期患者血清PCT、CRP水平稍高于健康对照组，两者比较差异不显著（P＞0．05）。相关性分析提示COPD急性加重患者PCT、CRP水平与FEV1％呈负相关（r＝－0．583，P＜0．01和r＝－0．318，P＜0．05）。结论 COPD急性加重患者血清PCT、CRP处于高水平，其变化与COPD患者病情分期关系密切，可作为COPD急性加重患者存在细菌感染及程度的判断指标，能反映COPD急性加重患者肺功能的损害。
목적：탐토COPD급성가중환자（ AECOPD）혈청강개소원（ PCT）、C반응단백（ CRP）수평변화급기여FEV1％예계치적상관성。방법측정40례COPD환자（급성가중기20례、은정기20례）、정상대조조적20례건강수시자혈청PCT、CRP수평，병분석COPD급성가중기PCT、CRP여제1초용력호기류량점예계치백분비（ FEV1％）적상관성。결과 COPD급성가중환자PCT、CRP수평고우은정기환자화대조조，차이유통계학의의（P＜0．05）。 COPD은정기환자혈청PCT、CRP수평초고우건강대조조，량자비교차이불현저（P＞0．05）。상관성분석제시COPD급성가중환자PCT、CRP수평여FEV1％정부상관（r＝－0．583，P＜0．01화r＝－0．318，P＜0．05）。결론 COPD급성가중환자혈청PCT、CRP처우고수평，기변화여COPD환자병정분기관계밀절，가작위COPD급성가중환자존재세균감염급정도적판단지표，능반영COPD급성가중환자폐공능적손해。
Objective To investigate the changes of pro-calcitonin and C-reactive protein levels in serum of patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) and the correlations with FEV1%.Methods The levels of PCT and CRP in serum were detected in 40 COPD patients (20 patients were in acute exacerbation and 20 patients in stationary phase) and 20 healthy subjects those who were enrolled in the control group, and observe the correlation between PCT, CRP and FEV1%.Results The levels of PCT and CRP in the acute exacerbation group were significantly higher than those in the stationary phase group and the control group ( P<0.05) ,and the levels of PCT and CRP in stationary phase group were higher than those in the control group, but the differences were not statistically significant(P>0.05),PCT and CRP levels in serum of AECOPD patients were negatively correlated with FEV1% (r =-0.583,P <0.01and r =-0.318,P <0.05). Conclusions PCT and CRP in serum of patients with AECOPD are often at a high level, the changes of them are intently related with disease staging and can be used as the judgment of bacterial infections and the severity of AECOPD, and it can reflect acute lung function damaging.