CAJ | 학술논문

目的：探讨替吉奥联合奥沙利铂方案治疗晚期胃癌的临床疗效。方法选取2010年1月～2013年1月广东医学院第二附属医院肿瘤科收治的晚期胃癌患者82例，随机分为2组(n=41)。对照组给予替吉奥治疗，观察组在对照组的基础上联合奥沙利铂治疗，对比2组临床效果。结果（1）观察组治疗后总有效率为84.53%，明显高于对照组的64.26%，差异有统计学意义（P＜0.05）；（2）治疗后2组患者均出现不同程度的恶心、呕吐等胃肠道不良反应及骨髓抑制等情况，但不良反应发生率比较，差异无统计学意义。结论替吉奥联合奥沙利铂方案治疗晚期胃癌的疗效显著，且安全性较高，值得临床推广应用。
목적：탐토체길오연합오사리박방안치료만기위암적림상료효。방법선취2010년1월～2013년1월엄동의학원제이부속의원종류과수치적만기위암환자82례，수궤분위2조(n=41)。대조조급여체길오치료，관찰조재대조조적기출상연합오사리박치료，대비2조림상효과。결과（1）관찰조치료후총유효솔위84.53%，명현고우대조조적64.26%，차이유통계학의의（P＜0.05）；（2）치료후2조환자균출현불동정도적악심、구토등위장도불량반응급골수억제등정황，단불량반응발생솔비교，차이무통계학의의。결론체길오연합오사리박방안치료만기위암적료효현저，차안전성교고，치득림상추엄응용。
Objective To explore for gonow joint scheme of oxaliplatin into the clinical curative effect of treatment of advanced gastric cancer, make guidance for clinical promotion. Methods Our hospital from January 2010 to January 2013, 82 cases of patients with advanced gastric cancer as the research object, its completely random divided into two groups, control group patients give for gonow treatment, observation group of patients in the control group on the basis of joint oxaliplatin into treatment, compared to observe clinical therapeutic effect of two groups of patients. Results (1)The observation group of patients after treatment the total effective rate was 84.53%, significantly higher than 64.26%, comparing the two groups statistically significant difference (P<0.05);(2)in the two groups after treatment in patients with different degree of gastrointestinal adverse reactions such as nausea, vomiting, and bone marrow suppression, etc., but the two groups the incidence of adverse reactions compared differences no statistical significance. Conclusion For gonow joint scheme of oxaliplatin into the clinical curative effect of treatment of advanced gastric cancer, and high security, is worth clinical popularizing widely.