当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
33期
94-95
,共2页
氨基末端B型利钠肽%心力衰竭%鉴别%诊断意义
氨基末耑B型利鈉肽%心力衰竭%鑒彆%診斷意義
안기말단B형리납태%심력쇠갈%감별%진단의의
Amino terminal B-type natriuretic peptide%Heart faliure%Identiifcation%Diagnostic value
目的：比较健康人和心力衰竭患者的氨基末端B型利钠肽（NT-proBNP）水平，探讨其对心力衰竭的诊断意义。方法对100例临床心力衰竭患者和40例健康人群同时进行超声心动图检查和NT-proBNP检测，比较2组观察指标差异。结果各级心力衰竭组的患者的氨基末端B型利钠肽水平均高于健康人群组。Ⅰ级12例患者（361.4±21.4），Ⅱ级36例患者（652.8±86.1），Ⅲ级41例患者（2741.5±351.2），Ⅳ级11例患者（7381.4±558.1），且随着心力衰竭的严重程度的增高，NT-proBNP水平也明显增高，差异有统计学意义（P<0.05）。在对照组（健康人群），NT-proBNP的检查结果为高龄大于低龄，女性高于男性，糖尿病和高血压组远高于非糖尿病和非高血压组（P<0.05）。在心力衰竭患者组，NT-proBNP的检查结果为高龄大于低龄，糖尿病和高血压组远高于非糖尿病和非高血压组（P<0.05），但是男性与女性比较差异无统计学意义。结论 NT-proBNP水平的检测对诊断心力衰竭有重要意义，但要充分考虑年龄、糖尿病、高血压等因素的影响，以便做出最正确的诊断。
目的：比較健康人和心力衰竭患者的氨基末耑B型利鈉肽（NT-proBNP）水平，探討其對心力衰竭的診斷意義。方法對100例臨床心力衰竭患者和40例健康人群同時進行超聲心動圖檢查和NT-proBNP檢測，比較2組觀察指標差異。結果各級心力衰竭組的患者的氨基末耑B型利鈉肽水平均高于健康人群組。Ⅰ級12例患者（361.4±21.4），Ⅱ級36例患者（652.8±86.1），Ⅲ級41例患者（2741.5±351.2），Ⅳ級11例患者（7381.4±558.1），且隨著心力衰竭的嚴重程度的增高，NT-proBNP水平也明顯增高，差異有統計學意義（P<0.05）。在對照組（健康人群），NT-proBNP的檢查結果為高齡大于低齡，女性高于男性，糖尿病和高血壓組遠高于非糖尿病和非高血壓組（P<0.05）。在心力衰竭患者組，NT-proBNP的檢查結果為高齡大于低齡，糖尿病和高血壓組遠高于非糖尿病和非高血壓組（P<0.05），但是男性與女性比較差異無統計學意義。結論 NT-proBNP水平的檢測對診斷心力衰竭有重要意義，但要充分攷慮年齡、糖尿病、高血壓等因素的影響，以便做齣最正確的診斷。
목적：비교건강인화심력쇠갈환자적안기말단B형리납태（NT-proBNP）수평，탐토기대심력쇠갈적진단의의。방법대100례림상심력쇠갈환자화40례건강인군동시진행초성심동도검사화NT-proBNP검측，비교2조관찰지표차이。결과각급심력쇠갈조적환자적안기말단B형리납태수평균고우건강인군조。Ⅰ급12례환자（361.4±21.4），Ⅱ급36례환자（652.8±86.1），Ⅲ급41례환자（2741.5±351.2），Ⅳ급11례환자（7381.4±558.1），차수착심력쇠갈적엄중정도적증고，NT-proBNP수평야명현증고，차이유통계학의의（P<0.05）。재대조조（건강인군），NT-proBNP적검사결과위고령대우저령，녀성고우남성，당뇨병화고혈압조원고우비당뇨병화비고혈압조（P<0.05）。재심력쇠갈환자조，NT-proBNP적검사결과위고령대우저령，당뇨병화고혈압조원고우비당뇨병화비고혈압조（P<0.05），단시남성여녀성비교차이무통계학의의。결론 NT-proBNP수평적검측대진단심력쇠갈유중요의의，단요충분고필년령、당뇨병、고혈압등인소적영향，이편주출최정학적진단。
Objective To explore the diagnostic values for heart faliure (HF) by comparing amino-terminal pro-brain natriuretic peptide(NT-proBNP) level of healthy people and patients with HF. Methods 100 HF patients and 40 healthy people were selected as the study objects,examed the objects by ultrasound cardiogram and detected their NT-proBNP,recorded and compared differences between two groups. Results NT-proBNP of all HF patients were significantly higher than healthy people, Grade I in 12 patients Patient(361.4±21.4),Grade Ⅱ in 36 patients Patient(652.8±86.1),Grade Ⅲ in 41 patients Patient(2741.5±351.2),Grade Ⅳ in 116 patients Patient(7381.4±558.1),and the NT-proBNP level increased when HF degree increased, differences were statistically signiifcant(P<0.05).In control group (healthy people), NT-proBNP of elderly people were higher than younger people, of female was higher than male, diabetes and hypertension group was higher than non-diabetes and hypertension group(P<0.05).In HF group, NT-proBNP detection showed that elderly people were higher than younger people, diabetes and hypertension group was higher than non-diabetes and hypertension group, there were no signiifcant differences between male and female. Conclusion NT-proBNP plays an improtant role in the diagnosis of HF, but factors such as age, hypertension, diabetes and so on should be fully considered during diagnosis, so as to make the right conclusion.
