CAJ | 학술논문

肝性脑病(hepatic encephalopathy,HE)是由急、慢性肝功能衰竭或各种门-体分流(porto-systemic venous shunting,PSS)引起的以代谢紊乱为基础的、并排除了其它已知脑病的中枢神经系统失调综合征。常以神经精神症状，如性格改变、行为异常、智力减退等为突出表现，发病机制复杂，但经过合理、及时治疗后，该综合征具有潜在的可逆性。如何选择合理有效的药物预防和防止肝性脑病复发，逆转患者的精神神经系统失调已经成为目前研究热点。笔者针对目前微生态制剂药物组成、作用机制、临床疗效及其对治疗肝性脑病的研究进展做一综述。
간성뇌병(hepatic encephalopathy,HE)시유급、만성간공능쇠갈혹각충문-체분류(porto-systemic venous shunting,PSS)인기적이대사문란위기출적、병배제료기타이지뇌병적중추신경계통실조종합정。상이신경정신증상，여성격개변、행위이상、지력감퇴등위돌출표현，발병궤제복잡，단경과합리、급시치료후，해종합정구유잠재적가역성。여하선택합리유효적약물예방화방지간성뇌병복발，역전환자적정신신경계통실조이경성위목전연구열점。필자침대목전미생태제제약물조성、작용궤제、림상료효급기대치료간성뇌병적연구진전주일종술。
Hepatic encephalopathy was result as acute or chronic liver failure or porto-systemic venous shunting which result in syndrome of central nervous system disorders based on metabolic disorders excluding other specific encephalopathies. Usually, it stands out with neuropsychiatric symptoms, such as character changing, behavior disorder, hypophrenia, etc. The pathogenesis is complicated, while with Reasonable and timely treatment, the syndrome may be reversible. Currently, the hot point in this field focuses on how to select reasonable and efficient medication to prevent the recurrence of hepatic encephalopathy and reverse the disordered neuropsychiatric symptoms. This review summarized probiotics drug component, pharmacological mechanism, clinical efficacy and applications in Hepatic encephalopathy.