实用中医药杂志
實用中醫藥雜誌
실용중의약잡지
JOURNAL OF PRACTICAL TRADITIONAL CHINESE MEDICINE
2014年
11期
990-993
,共4页
衰老%生殖内分泌%康寿益胶囊
衰老%生殖內分泌%康壽益膠囊
쇠로%생식내분비%강수익효낭
aging%reproductive endocrine%KangShouYi capsule
目的：研究中老年男性、绝经后妇女和绝经后更年期综合征患者生殖内分泌的改变，以及康寿益胶囊对中老年人生殖内分泌的影响。方法：临床症状采用3级评分法。实验室检测采用固相磁分离酶免疫分析法（Immunoenzymetric Assay，Magnetic Solid Phase）测定血清激素水平。男性测LH、T，女性测FSH、LH、E2。比较老年组和青年组、更年期综合征患者和无更年期综合征老年妇女生殖内分泌的改变，以及服用康寿益后对血清激素水平的影响。结果：随年龄老化，男性血清T水平下降，LH水平升高。绝经后妇女血清E2水平迅速下降，FSH、LH急剧升高。更年期综合征妇女较无更年期综合征妇女血清FSH、LH水平升高。服用康寿益3个月后，男性血清T水平升高显著、LH水平降低，更年期综合征妇女血清FSH、LH水平降低。康寿益能明显改善老年男性衰老症状，缓解老年女性更年期综合征症状，治疗前后临床症状评分有显著差异。结论：血清性激素（T、E2）随增龄而下降，促性腺激素（FSH、LH）反馈性升高。绝经后更年期综合征妇女血清FSH、LH水平升高更显著，可能有神经内分泌调节功能失调。康寿益能明显调整老年人（神经）生殖内分泌变化，改善衰老及更年期综合征症状表现。药理机制可能涉及到对衰老时中枢神经系统和下丘脑-垂体-性腺轴整合功能失调的多层次、多靶位调整作用。
目的：研究中老年男性、絕經後婦女和絕經後更年期綜閤徵患者生殖內分泌的改變，以及康壽益膠囊對中老年人生殖內分泌的影響。方法：臨床癥狀採用3級評分法。實驗室檢測採用固相磁分離酶免疫分析法（Immunoenzymetric Assay，Magnetic Solid Phase）測定血清激素水平。男性測LH、T，女性測FSH、LH、E2。比較老年組和青年組、更年期綜閤徵患者和無更年期綜閤徵老年婦女生殖內分泌的改變，以及服用康壽益後對血清激素水平的影響。結果：隨年齡老化，男性血清T水平下降，LH水平升高。絕經後婦女血清E2水平迅速下降，FSH、LH急劇升高。更年期綜閤徵婦女較無更年期綜閤徵婦女血清FSH、LH水平升高。服用康壽益3箇月後，男性血清T水平升高顯著、LH水平降低，更年期綜閤徵婦女血清FSH、LH水平降低。康壽益能明顯改善老年男性衰老癥狀，緩解老年女性更年期綜閤徵癥狀，治療前後臨床癥狀評分有顯著差異。結論：血清性激素（T、E2）隨增齡而下降，促性腺激素（FSH、LH）反饋性升高。絕經後更年期綜閤徵婦女血清FSH、LH水平升高更顯著，可能有神經內分泌調節功能失調。康壽益能明顯調整老年人（神經）生殖內分泌變化，改善衰老及更年期綜閤徵癥狀錶現。藥理機製可能涉及到對衰老時中樞神經繫統和下丘腦-垂體-性腺軸整閤功能失調的多層次、多靶位調整作用。
목적：연구중노년남성、절경후부녀화절경후경년기종합정환자생식내분비적개변，이급강수익효낭대중노년인생식내분비적영향。방법：림상증상채용3급평분법。실험실검측채용고상자분리매면역분석법（Immunoenzymetric Assay，Magnetic Solid Phase）측정혈청격소수평。남성측LH、T，녀성측FSH、LH、E2。비교노년조화청년조、경년기종합정환자화무경년기종합정노년부녀생식내분비적개변，이급복용강수익후대혈청격소수평적영향。결과：수년령노화，남성혈청T수평하강，LH수평승고。절경후부녀혈청E2수평신속하강，FSH、LH급극승고。경년기종합정부녀교무경년기종합정부녀혈청FSH、LH수평승고。복용강수익3개월후，남성혈청T수평승고현저、LH수평강저，경년기종합정부녀혈청FSH、LH수평강저。강수익능명현개선노년남성쇠로증상，완해노년녀성경년기종합정증상，치료전후림상증상평분유현저차이。결론：혈청성격소（T、E2）수증령이하강，촉성선격소（FSH、LH）반궤성승고。절경후경년기종합정부녀혈청FSH、LH수평승고경현저，가능유신경내분비조절공능실조。강수익능명현조정노년인（신경）생식내분비변화，개선쇠로급경년기종합정증상표현。약리궤제가능섭급도대쇠로시중추신경계통화하구뇌-수체-성선축정합공능실조적다층차、다파위조정작용。
Objective:To investigate the changes of reproductive endocrine in older men、postmenopausal women、postmenopausal women with menopausal symptoms,and the effects of KangShouYi capsule on reproductive endocrine in eldly individuals.Methods:All symptoms were standardized by three-grade score.Serum sex hormones and gonadotropin concentrations were quantitated in an.immunoenzymetric assay ( magnetic solid phase).We compared variations of reproductive endocrine between old individuls and young controls,women with menopausal symptoms and age-matched women.We also observed the effects of KangShouYi on serum hormones.Results:In males,serum testosterone(T)decreased ,luteinizing hormones(LH) increased significantly in human aging. Serum estrogen(E2)decreased,follicle-stimulating hormone (FSH) and luteinizing hormone(LH)elevated dramatically in postmenopausal women. Compared with postmenopausal woman with no menopausal syndrome,serum FSH,LH levels increased statiscally in women with symptoms. Following three-month KangShouYi treatment,serum T levels increased ,LH decreased in old males. Following three-month KangShouYi treatment,serum FSH, LH levels decreased in old females,E2 levels increased with no significance. After treatment,the scales of clinical symptoms was inproved obviously.Conclusion:Serum sex hormone(E2,T)levels decreased with aging,and FSH,LH levels increased because of the failing negative feedback. menopausal syndrome women present high FSH,LH levels which is correlated to the irrgeulation of neural endocrine.KangShouYi can regulate the function of(neural)reproductive endocrine in older individuls, retard aging,release the suffering of menopausal syndrome patients.
