CAJ | 학술논문

目的：研究丹皮酚对动脉粥样硬化（AS）大鼠的抗氧化作用。方法：用高脂饲料喂养和维生素D3腹腔注射的方法建立大鼠AS模型，然后分为正常组、模型组、阳性组（辛伐他汀10 mg/kg）、丹皮酚3个剂量组（20、10、5mg/kg），每组10只。灌胃给药4周后各组取主动脉，在光镜下进行病变分级评分。取血清测定SOD活力和MDA含量。结果：丹皮酚能改善AS大鼠的主动脉病变，高剂量组与模型组比较差异有统计学意义（P＜0.05）。与模型组比较，丹皮酚各剂量组AS大鼠血清SOD活性显著升高（P＜0.01），血清MDA含量降低（P＜0.05或P＜0.01）。结论：丹皮酚治疗AS作用可能与增强SOD活性、减少MDA含量、减轻氧自由基的损伤有关。
목적：연구단피분대동맥죽양경화（AS）대서적항양화작용。방법：용고지사료위양화유생소D3복강주사적방법건립대서AS모형，연후분위정상조、모형조、양성조（신벌타정10 mg/kg）、단피분3개제량조（20、10、5mg/kg），매조10지。관위급약4주후각조취주동맥，재광경하진행병변분급평분。취혈청측정SOD활력화MDA함량。결과：단피분능개선AS대서적주동맥병변，고제량조여모형조비교차이유통계학의의（P＜0.05）。여모형조비교，단피분각제량조AS대서혈청SOD활성현저승고（P＜0.01），혈청MDA함량강저（P＜0.05혹P＜0.01）。결론：단피분치료AS작용가능여증강SOD활성、감소MDA함량、감경양자유기적손상유관。
Objective:To investigate the anti-oxidative stress effect of paeonol (PA) against atherosclerosis(AS) in rats.Methods:Rats model of AS was established by administration of high-fat diet and vitamin D3 (i.p.).Rats were divided into 6 groups(n = 10)at random,namely normal,model,positive(simvastatin,10 mg/kg)and PA high,medium and low dose groups(20,10 and 5 mg/kg,respectively). After 4 weeks of oral treatment,the aortic pathologic changes were observed under microscope and graded.The sera of all rats were collected to determine the SOD activities and MDA contents.Results:Administration of PA improved the severity of aortic pathology in AS rats,and the pathologic grade of PA high dose group showed a significant difference compared with that of model group(P<0.05).PA (20,10 and 5 mg/kg)significantly increased the SOD activities(P<0.01)and reduced the MDA contents(P<0.05 or P<0.01)in serum of AS rats compared to the model group.Conclusion:Therapeutic effect of PA against AS maybe due to its action on SOD activities and MDA contents.