CAJ | 학술논문

目的：观察光动力疗法（PDT ）联合Lucentis玻璃体腔注射治疗脉络膜新生血管疾病（CNV ）的近期疗效和安全性。方法对30例（30只眼）经眼压、眼底检查、荧光素眼底血管造影（FFA）以及光学相干断层扫描（OCT ）等检查确诊为 CNV 患者行 PDT 联合 Lucentis 玻璃体腔注射治疗的患者资料进行回顾性分析。结果经4～6个月随访，30只眼中有22只眼视力提高（占73．3％），8只眼视力稳定（占26．7％），未见有视力下降者。20例 AMD 患者中14例（70．0％）通过一次联合治疗后 CNV 消退；3例（15．0％）3个月后需再次 Lucentis 玻璃体腔注射治疗。10例特发性脉络膜新生血管病例通过一次联合治疗而使 CNV 消退。治疗及随访期间无全身和眼部并发症发生。结论 PDT 联合 Lucentis 玻璃体腔注射治疗 CNV 的疗效显著，可以提高患者视力及减少重复治疗的次数。
목적：관찰광동력요법（PDT ）연합Lucentis파리체강주사치료맥락막신생혈관질병（CNV ）적근기료효화안전성。방법대30례（30지안）경안압、안저검사、형광소안저혈관조영（FFA）이급광학상간단층소묘（OCT ）등검사학진위 CNV 환자행 PDT 연합 Lucentis 파리체강주사치료적환자자료진행회고성분석。결과경4～6개월수방，30지안중유22지안시력제고（점73．3％），8지안시력은정（점26．7％），미견유시력하강자。20례 AMD 환자중14례（70．0％）통과일차연합치료후 CNV 소퇴；3례（15．0％）3개월후수재차 Lucentis 파리체강주사치료。10례특발성맥락막신생혈관병례통과일차연합치료이사 CNV 소퇴。치료급수방기간무전신화안부병발증발생。결론 PDT 연합 Lucentis 파리체강주사치료 CNV 적료효현저，가이제고환자시력급감소중복치료적차수。
Objective To investigate the efficacy and safety of photodynamic therapy(PDT) combined with vitreous cavity injec‐tion of Lucentis treatment for choroidal neovascularization(CNV) diseases .Methods we retrospectively analyzed data of 30 cases (30 eyes) of CNV ,who was diagnosed by examination of visual acuity ,intmocular pressure ,ocular fundus ,fundus fluorescein angi‐ography (FFA) ,and optic coherence tomography(OCT) ,and who underwent PDT combined with intravitreal injection of Lucentis . Results At the 4 ~ 6 months follow‐up ,the best corrected visual acuity(BCVA) improved in 22 eyes(73 .3% ) ,stabilized in 8 eyes (26 .7% ) and none decreased .Among the AMD ,14 cases(70 .0% ) required only a single combined treatment for CNV resolution ;3 cases of AMD needed retreatment 3 months later .In CNV group ,all of the cases required only a single combined treatment for CNV resolution .At the therapy and follow‐up period ,no ocular or systemic adverse reactions were noted .Conclusion The treatment of PDT combine intravitreal injection of Lucentis is safe and effective for CNV ,which could improve visual acuity and reduce retreat‐ment rates .