CAJ | 학술논문

目的：探讨降低血尿酸（SUA）水平对高血压合并无症状高尿酸血症（HUA）患者血压控制以及肾功能的影响。方法将148例原发性高血压合并无症状HUA的患者分为治疗组及对照组，治疗组使用苯溴马隆、低嘌呤食物饮食，对照组给予安慰剂及普通饮食。两组给予降压药物治疗。观察两组患者治疗前后血压、SUA、肌酐（Cr）、肌酐清除率（Ccr）、24h尿蛋白定量（MAU）、血清β2微球蛋白（β2‐MG）的变化，记录苯溴马隆不良反应的情况。结果治疗组患者经治疗后各时间点的收缩压（SBP）、舒张压（DBP）均显著下降，1个月后SUA水平较治疗前显著下降；与对照组相比，治疗组患者血压水平3个月后均显著低于对照组，SUA水平至1个月后的各时间点均显著低于对照组，血Cr、Ccr、MAU、血清β2‐MG水平在3个月及6个月时均显著低于对照组（P＜0．05）。结论高血压合并无症状HUA患者经降SUA治疗，能有效降低血压，保护肾功能。
목적：탐토강저혈뇨산（SUA）수평대고혈압합병무증상고뇨산혈증（HUA）환자혈압공제이급신공능적영향。방법장148례원발성고혈압합병무증상HUA적환자분위치료조급대조조，치료조사용분추마륭、저표령식물음식，대조조급여안위제급보통음식。량조급여강압약물치료。관찰량조환자치료전후혈압、SUA、기항（Cr）、기항청제솔（Ccr）、24h뇨단백정량（MAU）、혈청β2미구단백（β2‐MG）적변화，기록분추마륭불량반응적정황。결과치료조환자경치료후각시간점적수축압（SBP）、서장압（DBP）균현저하강，1개월후SUA수평교치료전현저하강；여대조조상비，치료조환자혈압수평3개월후균현저저우대조조，SUA수평지1개월후적각시간점균현저저우대조조，혈Cr、Ccr、MAU、혈청β2‐MG수평재3개월급6개월시균현저저우대조조（P＜0．05）。결론고혈압합병무증상HUA환자경강SUA치료，능유효강저혈압，보호신공능。
Objective To investigate the effect of the reduction of serum uric acid(SUA) on blood pressure(BP) control and re‐nal function protection in hypertensive patients with asymptomatic hyperuricemia (HUA) .Methods One hundred and forty‐eight hypertensive patients with asymptomatic HUA were randomly divided into two groups ,namely HUA reduction group and control group .Patients in HUA reduction group was provided with benzbromarone and low purine food ,while patients in control group was given placebo and ordinary diet .All patients were given the same method of antihypertensive drugs .Follow up was preformed for 6 months ,data of BP ,SUA ,creatinine(Cr) ,creatinine clearance(Ccr) ,24 h microalbuminuria quantity(MAU) ,serumβ2 microglobulin (β2‐MG)and adverse reactions were recorded and analyzed .Results The systolic blood pressure(SBP) and diastolic blood pressure (DBP) of patients in HUA reduction group significantly decreased immediately after being treated ,while SUA decreased 1 month after being treated .Compared with control group ,the average SBP and DBP of patients in HUA reduction group was significantly lower 3 months after being treated;the SUA was significantly lower 1 months after being treated ,the levels of Cr ,Ccr ,MAU andβ2‐MG was significantly lower at 3 months and 6 months after being treated (P<0 .05) .Conclusion The SUA therapy can effec‐tively lower BP and SUA levels of primary hypertensive patients with asymptomatic HUA while protecting renal function .