CAJ | 학술논문

目的：研究甲状腺功能亢进（简称甲亢）对大鼠红细胞系列指标及血清铁的影响。方法SD雌性大鼠分为甲亢模型组和对照组，优甲乐灌胃制造甲亢模型，对照组灌服生理盐水。分别在灌胃给药后的第1～8周采血，采用放射免疫法测定大鼠血清三碘甲状腺原氨酸（T3）、四碘甲状腺原氨酸（T4）及促甲状腺激素（TSH）含量；使用全自动血细胞分析仪测定大鼠红细胞系列指标；比色法测定血清铁含量和总铁结合力。结果甲亢模型组大鼠血清T3、T4含量增高，而TSH含量下降。甲亢模型组大鼠红细胞计数（RBC）在第2～8周均明显高于对照组（P＜0．05）；红细胞压积（HCT）在第1～8周均明显高于对照组（P＜0．01）；平均红细胞体积（MCV）在第2～8周均明显低于对照组（P＜0．05）；平均细胞血红蛋白浓度（MCHC）在第1～8周均明显低于对照组（P＜0．01）；红细胞体积分布宽度标准差（RDW‐SD）和红细胞体积分布宽度变异系数（RDW‐CV）在第1～2周均高于对照组（P＜0．01）；血清铁含量和总铁结合力在第4～8周均高于对照组（P＜0．01）。结论本实验甲亢模型鼠虽未出现明显的贫血表现，但红细胞有明显的低色素性改变，血清铁含量和血清铁结合力均升高，提示有铁利用障碍。
목적：연구갑상선공능항진（간칭갑항）대대서홍세포계렬지표급혈청철적영향。방법SD자성대서분위갑항모형조화대조조，우갑악관위제조갑항모형，대조조관복생리염수。분별재관위급약후적제1～8주채혈，채용방사면역법측정대서혈청삼전갑상선원안산（T3）、사전갑상선원안산（T4）급촉갑상선격소（TSH）함량；사용전자동혈세포분석의측정대서홍세포계렬지표；비색법측정혈청철함량화총철결합력。결과갑항모형조대서혈청T3、T4함량증고，이TSH함량하강。갑항모형조대서홍세포계수（RBC）재제2～8주균명현고우대조조（P＜0．05）；홍세포압적（HCT）재제1～8주균명현고우대조조（P＜0．01）；평균홍세포체적（MCV）재제2～8주균명현저우대조조（P＜0．05）；평균세포혈홍단백농도（MCHC）재제1～8주균명현저우대조조（P＜0．01）；홍세포체적분포관도표준차（RDW‐SD）화홍세포체적분포관도변이계수（RDW‐CV）재제1～2주균고우대조조（P＜0．01）；혈청철함량화총철결합력재제4～8주균고우대조조（P＜0．01）。결론본실험갑항모형서수미출현명현적빈혈표현，단홍세포유명현적저색소성개변，혈청철함량화혈청철결합력균승고，제시유철이용장애。
Objective To study the change of erythrocyte indices and serum iron in hyperthyroidism rats .Methods SD female rats were randomly divided into hyperthyroidism group and control group .Hyperthyroidism rats were induced by intragastric ad‐ministration of Euthyrox (Levothyroxine) and their blood and serum were obtained after administration of 1-8 weeks ,respective‐ly .And the control rats were given normal saline .Levels of T3 ,T4 and TSH were determined by a radioimmunoassay .Erythrocyte index were measured by automatic blood cell analyzer .Serum iron concentration and total iron binding capacity were determined by chromatometry .Results The concentration of serum T3 and T4 increased in hyperthyroidism rats ,whereas the TSH decreased . RBC was higher in hyperthyroidism rats at 2-8 weeks compared with the control rats (P<0 .05) .HCT was higher in hyperthy‐roidism rats at 1-8 weeks compared with the control rats (P<0 .01) .MCV was lower in hyperthyroidism rats at 2-8 weeks com‐pared with the control rats (P<0 .05) .MCHC was lower in hyperthyroidism rats at 1 -8 weeks compared with the control rats (P<0 .01) .RDW SD and RDW CV was higher hyperthyroidism rats at 1-2 weeks compared with the control rats(P<0 .01) .Ser‐um iron concentration and total iron binding capacity increased in hyperthyroidism rats at 4 -8 weeks compared with the control rats(P<0 .01) .Conclusion The hyperthyroidism rats in the present study is absent significant manifestation of anemia ,whereas the hypochromic changes of erythrocyte is significant .Serum iron concentration and total iron binding capacity increase in hyperthy‐roidism rats ,which demonstrate the iron utilization disorder .