CAJ | 학술논문

目的：观察野百合碱（MCT）致右心室肥厚大鼠血流动力学的变化。方法SD大鼠单次腹腔注射MCT60mg/kg，以右心室/体质量（RV/BW）、右室肥厚指数（RVHI）及心房利钠因子（ANF）mRNA的表达为心肌肥厚指标。10％水合氯醛腹腔麻醉，颈总动脉插管及右心室插管，测量右心室血流动力学指标。结果溶媒对照各组大鼠RV/BW、RVHI和ANFmRNA无明显变化。MCT给药后，M2W和M4W组心肌肥厚各指标明显增加（P＜0．01），右心室肥厚形成。溶媒对照各组右心室血流动力学各指标无明显变化。MCT模型组，心率（HR）及血压无改变。其中M2W组，RVEDP明显下降（P＜0．01），其余指标明显升高（P＜0．01）；M4W组各项指标均明显升高（P＜0．01）。结论MCT在致心肌肥厚的同时，右心室收缩和舒张功能受损；进一步发展的结果可能导致右心功能衰竭。
목적：관찰야백합감（MCT）치우심실비후대서혈류동역학적변화。방법SD대서단차복강주사MCT60mg/kg，이우심실/체질량（RV/BW）、우실비후지수（RVHI）급심방리납인자（ANF）mRNA적표체위심기비후지표。10％수합록철복강마취，경총동맥삽관급우심실삽관，측량우심실혈류동역학지표。결과용매대조각조대서RV/BW、RVHI화ANFmRNA무명현변화。MCT급약후，M2W화M4W조심기비후각지표명현증가（P＜0．01），우심실비후형성。용매대조각조우심실혈류동역학각지표무명현변화。MCT모형조，심솔（HR）급혈압무개변。기중M2W조，RVEDP명현하강（P＜0．01），기여지표명현승고（P＜0．01）；M4W조각항지표균명현승고（P＜0．01）。결론MCT재치심기비후적동시，우심실수축화서장공능수손；진일보발전적결과가능도치우심공능쇠갈。
Objective To observe the hemodynamic changes on right ventricular hypertrophy induced by monocrotaline in rats . Methods Male SD rats were given monocrotaline 60 mg/kg by a single intraperitoneal injection ,the mRNA expression of RV/BW , RVHI and ANF were took as the indicators .Intraperitoneal injection with 10% chloral hydrate was performed ,the artery cannulae and right ventricular catheter were inserted ,and the right ventricle pressure was measured .Results The RVHI and RV/BW were significantly increased in M2W and M4W groups ,compared with vehicle control (P<0 .01) ,and the ANF mRNA expression was significantly increased in both groups .Bp and HR did not change in model groups .RVEDP markedly decreased (P< 0 .01) and RVP ,± dp/dtmax ,t dp/dtmax and Vpm increased (P<0 .001) in M2W groups ;and all parameters increased significantly in M4W groups (P<0 .01) .Conclusion Monocrotaline can induce RVH ,which accompany hemodynamic changes and the systolic and dias‐tolic dysfunction in right ventricle may eventually cause right heart failure .