CAJ | 학술논문

目的：探讨慢性肾脏疾病（CKD）患者中血清半乳糖凝集素‐3（Gal‐3）的水平及其临床意义。方法采用ELISA检测健康对照组（34例）及CKD组（38例）中血清Gal‐3水平，采用全自动生化分析仪测定肾功能，并分析其与CKD分期的关系。结果 CKD组中Gal‐3血清水平（1．22±1．01）ng/mL显著低于健康对照组（3．03±2．06）ng/mL ，差异有统计学意义（P＜0．05）；血清Gal‐3水平与血清Cr、CysC水平呈负相关（P＜0．05）。结论血清Gal‐3水平与CKD患者肾损害程度密切相关，可作为判断CKD肾损害程度的生化指标。
목적：탐토만성신장질병（CKD）환자중혈청반유당응집소‐3（Gal‐3）적수평급기림상의의。방법채용ELISA검측건강대조조（34례）급CKD조（38례）중혈청Gal‐3수평，채용전자동생화분석의측정신공능，병분석기여CKD분기적관계。결과 CKD조중Gal‐3혈청수평（1．22±1．01）ng/mL현저저우건강대조조（3．03±2．06）ng/mL ，차이유통계학의의（P＜0．05）；혈청Gal‐3수평여혈청Cr、CysC수평정부상관（P＜0．05）。결론혈청Gal‐3수평여CKD환자신손해정도밀절상관，가작위판단CKD신손해정도적생화지표。
Objective To detect serum galectin 3 levels in patients with chronic kidney disease (CKD) and explore its clinical significance .Methods The galectin 3 levels the serum of in 38 CKD patients and 34 healthy controls were determined by ELISA . All kidney function was measured by automatic biochemical analyzer .The relation between serum galectin 3 levels and the level of kidney function was analyzed by use of t test .Results The serum galectin 3 levels in CKD and healthy controls groups were (1 .22 ± 1 .01)ng/mL and (3 .03 ± 2 .06)ng/mL ,P<0 .05 .There was close negative correlation between serum levels of galectin 3 and Cr ,CysC(P<0 .05) .Conclusion Serum galectin 3 of CKD patients reduces significantly and correlates with kidney function . Detecting on s galectin 3 is helpful for chronic kidney disease diagnosis and therapeutic effect evaluation .