河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
1期
55-58
,共4页
血清sTWEAK%冠心病%急性心肌梗死
血清sTWEAK%冠心病%急性心肌梗死
혈청sTWEAK%관심병%급성심기경사
Serum sTWEAK%Coronary heart disease%Acute myocardial infarction
目的：探讨分析人可溶性肿瘤坏死因子样凋亡弱诱导因子（ sTWEAK ）与冠心病（ CHD ）严重程度的关系及其对急性心肌梗死（ AMI）发病的预测价值。方法：对在本院住院治疗的176例冠心病患者随机分组，其中包括不稳定性心绞痛（ UAP ）组患者98例、稳定性心绞痛（ SAP ）组患者18例、急性心肌梗死（ AMI）组患者60例，同时选取无冠心病史的36例患者为对照组。采用sTWEAK ELISA 试剂盒对血sTWEAK的浓度进行测定，CHD 严重程度的评估采用冠状动脉造影Gensini 评分方法。结果：60例AMI患者临床监测的sTWEAK的浓度明显高于其他患者，差异有统计学意义（ P＜0．05）；监测到的sTWEAK临床实际浓度与Gensini评分呈正相关，可将其视为AMI的高危因素之一，差异有统计学意义（ P＜0．05）。结论：对于急性心肌梗死患者而言，血清sTWEAK 的浓度水平高于非AMI患者以及对照组患者，故在临床中可将sTWEAK 视为AMI 发生的危险因素且其与CHD 严重程度正相关。
目的：探討分析人可溶性腫瘤壞死因子樣凋亡弱誘導因子（ sTWEAK ）與冠心病（ CHD ）嚴重程度的關繫及其對急性心肌梗死（ AMI）髮病的預測價值。方法：對在本院住院治療的176例冠心病患者隨機分組，其中包括不穩定性心絞痛（ UAP ）組患者98例、穩定性心絞痛（ SAP ）組患者18例、急性心肌梗死（ AMI）組患者60例，同時選取無冠心病史的36例患者為對照組。採用sTWEAK ELISA 試劑盒對血sTWEAK的濃度進行測定，CHD 嚴重程度的評估採用冠狀動脈造影Gensini 評分方法。結果：60例AMI患者臨床鑑測的sTWEAK的濃度明顯高于其他患者，差異有統計學意義（ P＜0．05）；鑑測到的sTWEAK臨床實際濃度與Gensini評分呈正相關，可將其視為AMI的高危因素之一，差異有統計學意義（ P＜0．05）。結論：對于急性心肌梗死患者而言，血清sTWEAK 的濃度水平高于非AMI患者以及對照組患者，故在臨床中可將sTWEAK 視為AMI 髮生的危險因素且其與CHD 嚴重程度正相關。
목적：탐토분석인가용성종류배사인자양조망약유도인자（ sTWEAK ）여관심병（ CHD ）엄중정도적관계급기대급성심기경사（ AMI）발병적예측개치。방법：대재본원주원치료적176례관심병환자수궤분조，기중포괄불은정성심교통（ UAP ）조환자98례、은정성심교통（ SAP ）조환자18례、급성심기경사（ AMI）조환자60례，동시선취무관심병사적36례환자위대조조。채용sTWEAK ELISA 시제합대혈sTWEAK적농도진행측정，CHD 엄중정도적평고채용관상동맥조영Gensini 평분방법。결과：60례AMI환자림상감측적sTWEAK적농도명현고우기타환자，차이유통계학의의（ P＜0．05）；감측도적sTWEAK림상실제농도여Gensini평분정정상관，가장기시위AMI적고위인소지일，차이유통계학의의（ P＜0．05）。결론：대우급성심기경사환자이언，혈청sTWEAK 적농도수평고우비AMI환자이급대조조환자，고재림상중가장sTWEAK 시위AMI 발생적위험인소차기여CHD 엄중정도정상관。
Objective:To investigate the relationship between human soluble tumor necrosis factor-like apoptosis weak inducible factor ( sTWEAK ) with severity of coronary heart disease and its predictive value for acute myocardial infarction ( AMI). Method:176 cases with CHD in our hospital, including 98 patients with unstable angina pectoris ( UAP group ), 18 patients with stable angina pectoris ( SAP group ), 60 pa-tients with acute myocardial infarction ( AMI group ) and 36 cases in normal control group. The sTWEAK concentration was measured by sTWEAK ELISA and the assessment of the severity of CHD were used by cor -onary angiography Gensini score method. Result:sTWEAK concentration of 60 patients with AMI were sig-nificantly higher than the other patients, the difference was statistically significant ( P<0.05); the clinical actual concentration of sTWEAK had positively correlated with Gensini scores, and it can be regarded as one of the factors for high-risk of AMI, the difference was statistically significant (P<0.05).Conclusion: For the patients with acute myocardial infarction, the serum sTWEAK concentration level is higher than the non-AMI patients and the control group patients, Therefore, sTWEAK is regarded as a risk factor for the onset of AMI and its positive correlation with CHD severity.
