CAJ | 학술논문

目的：观察阿托伐他汀对糖尿病肾病患者肾功能相关血清指标及肾脏纤维化的影响。方法：选取本院2011年4月至2013年6月收治的80例糖尿病肾病患者为研究对象，将80例糖尿病肾病患者遵循随机分配的原则分为对照组（常规糖尿病肾病治疗组）40例和观察组（常规糖尿病肾病治疗加阿托伐他汀组）40例，然后将两组糖尿病肾病患者治疗前与治疗后6周、12周及24周时的肾功能相关血清指标及肾脏纤维化指标进行分别检测与比较。结果：观察组患者在治疗后6周、12周及24周时的血清β2－MG、hs－CRP、Scr及UA等肾功能相关指标均低于对照组，且CysC、TIMP－1、TGF－β1及CⅣ等肾纤维化指标也显著地低于对照组， P 均＜0．05。结论：阿托伐他汀可有效改善糖尿病肾病患者的肾功能及肾脏纤维化，对于上述方面的相关血清指标有较佳的控制作用。
목적：관찰아탁벌타정대당뇨병신병환자신공능상관혈청지표급신장섬유화적영향。방법：선취본원2011년4월지2013년6월수치적80례당뇨병신병환자위연구대상，장80례당뇨병신병환자준순수궤분배적원칙분위대조조（상규당뇨병신병치료조）40례화관찰조（상규당뇨병신병치료가아탁벌타정조）40례，연후장량조당뇨병신병환자치료전여치료후6주、12주급24주시적신공능상관혈청지표급신장섬유화지표진행분별검측여비교。결과：관찰조환자재치료후6주、12주급24주시적혈청β2－MG、hs－CRP、Scr급UA등신공능상관지표균저우대조조，차CysC、TIMP－1、TGF－β1급CⅣ등신섬유화지표야현저지저우대조조， P 균＜0．05。결론：아탁벌타정가유효개선당뇨병신병환자적신공능급신장섬유화，대우상술방면적상관혈청지표유교가적공제작용。
Objective:To observe the influence of atorvastatin for the renal function related serum inde-xes and renal fibrosis of patients with diabetic nephropathy ( DN).Method:80 patients with diabetic ne-phropathy in our hospital from April 2011 to June 2013 were as the study object ,They were divided into con-trol group ( conventional diabetic nephropathy treatment group ) with 40 cases and observation group ( conven-tional diabetic nephropathy treatment and atorvastatin group ) with 40 cases according to the method of random allocation,then the renal function related serum indexes and renal fibrosis indexes of two groups before the treatment and at 6th,12th and 24th week after the treatment were respectively detected and compared .Re-sult:The renal function related indexes including serum β2-MG,hs-CRP,Scr and UA of observation group at 6th,12th and 24th week after the treatment were all lower than those of control group ,renal fibrosis indexes including CysC ,TIMP-1,TGF-β1 and CⅣwere all significantly lower than those of control group too ,all P<0.05.Conclusion:The atorvastatin can effectively improve the renal function and renal fibrosis of patients with diabetic nephropathy ,and it has better role for the control of those related serum indexes .