河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
1期
13-16
,共4页
孙奕飞%杨占风%郁海燕%张李娜
孫奕飛%楊佔風%鬱海燕%張李娜
손혁비%양점풍%욱해연%장리나
脂联素%肿瘤细胞因子-α%胰岛素抵抗%冠心病%非酒精性脂肪肝
脂聯素%腫瘤細胞因子-α%胰島素牴抗%冠心病%非酒精性脂肪肝
지련소%종류세포인자-α%이도소저항%관심병%비주정성지방간
Adiponectin%Tumor cell factor-α%Insulin resistance%Coronary heart disease%Non alcoholic fatty liver
目的：探讨冠心病并发非酒精性脂肪肝患者以及单纯冠心病患者血清中脂联素（ APN）、肿瘤细胞因子－α（ TNF－α）及胰岛素抵抗（ IR）之间的关系。方法：将我院收治的240例冠心病患者根据是否并发非酒精性脂肪肝进行分组，其中冠心病并发非酒精性脂肪肝组与单纯冠心病组每组各120例。分别检测两组患者血清中APN、TNF－α以及IR含量，分析其与CHD并发NAFLD的联系。结果：冠心病并发非酒精性脂肪肝组120例患者血清中APN水平明显低于单纯冠心病组（P＜0．05），TNF－α水平则明显高于单纯冠心病组（ P＜0．05）。 APN与IR呈显著负相关，但IR在NAFLD、CHD中的因果关系尚不十分明确，有待进一步探讨。结论：APN、TNF－α以及IR水平测定对于减少NAFLD的发生具有重要意义，从而使CHD发生率降低。
目的：探討冠心病併髮非酒精性脂肪肝患者以及單純冠心病患者血清中脂聯素（ APN）、腫瘤細胞因子－α（ TNF－α）及胰島素牴抗（ IR）之間的關繫。方法：將我院收治的240例冠心病患者根據是否併髮非酒精性脂肪肝進行分組，其中冠心病併髮非酒精性脂肪肝組與單純冠心病組每組各120例。分彆檢測兩組患者血清中APN、TNF－α以及IR含量，分析其與CHD併髮NAFLD的聯繫。結果：冠心病併髮非酒精性脂肪肝組120例患者血清中APN水平明顯低于單純冠心病組（P＜0．05），TNF－α水平則明顯高于單純冠心病組（ P＜0．05）。 APN與IR呈顯著負相關，但IR在NAFLD、CHD中的因果關繫尚不十分明確，有待進一步探討。結論：APN、TNF－α以及IR水平測定對于減少NAFLD的髮生具有重要意義，從而使CHD髮生率降低。
목적：탐토관심병병발비주정성지방간환자이급단순관심병환자혈청중지련소（ APN）、종류세포인자－α（ TNF－α）급이도소저항（ IR）지간적관계。방법：장아원수치적240례관심병환자근거시부병발비주정성지방간진행분조，기중관심병병발비주정성지방간조여단순관심병조매조각120례。분별검측량조환자혈청중APN、TNF－α이급IR함량，분석기여CHD병발NAFLD적련계。결과：관심병병발비주정성지방간조120례환자혈청중APN수평명현저우단순관심병조（P＜0．05），TNF－α수평칙명현고우단순관심병조（ P＜0．05）。 APN여IR정현저부상관，단IR재NAFLD、CHD중적인과관계상불십분명학，유대진일보탐토。결론：APN、TNF－α이급IR수평측정대우감소NAFLD적발생구유중요의의，종이사CHD발생솔강저。
Objective:To investigate patients with coronary heart disease complicated with nonalcoholic fatty liver and serum adiponectin with coronary heart disease ( APN) , tumor cell factor alpha ( TNF-α) and insulin resistance ( IR) and the relationship between .Method: 240 patients were treated in our hospital , complicated with non alcoholic fatty liver , were divided according to the coronary heart disease complicated with non alcoholic fatty liver group and simple CHD group , each with 120 cases.Two groups of patients with serum APN, TNF-αand IR content were detected , and then analyzed the relationship with CHD complicat-ed with NAFLD.Results:Coronary heart disease complicated with nonalcoholic fatty liver group of 120 pa-tients with serum APN levels were significantly lower than the simple CHD group ( P<0.05) , TNF-αlevel was significantly higher than the group of coronary heart disease ( P<0.05 ) .There was significant negative correlation between APN and IR , but the causal relation in NAFLD , IR in CHD was not very clear , need further study.Conclusion:The determination of APN, TNF-αand IR levels has important meaning to re-duce the incidence of NAFLD , so that CHD can reduce the incidence rate .
