CAJ | 학술논문

目的：探讨B23和Ki67与宫颈癌预后的关系。方法：免疫组织化学染色检测104例宫颈癌及20例正常宫颈组织中B23和Ki67的表达水平，统计学分析宫颈癌患者生存率与B23和Ki67的表达水平的关系。结果：B23在正常宫颈组织和宫颈癌组织中的阳性率分别为30．0％和76．9％（ P＜0．001）。 Ki67在正常宫颈组织和宫颈癌组织中阳性率分别为15．0％和44．2％（ P＝0．014）。单因素分析显示B23及Ki67的表达与宫颈癌的无进展生存率呈负相关。 B23和Ki67的表达存在正相关关系（ P＜0．05）。结论：联合检测B23和Ki67可能有助于判断宫颈癌的生存率，作为临床疗效的预后指标。
목적：탐토B23화Ki67여궁경암예후적관계。방법：면역조직화학염색검측104례궁경암급20례정상궁경조직중B23화Ki67적표체수평，통계학분석궁경암환자생존솔여B23화Ki67적표체수평적관계。결과：B23재정상궁경조직화궁경암조직중적양성솔분별위30．0％화76．9％（ P＜0．001）。 Ki67재정상궁경조직화궁경암조직중양성솔분별위15．0％화44．2％（ P＝0．014）。단인소분석현시B23급Ki67적표체여궁경암적무진전생존솔정부상관。 B23화Ki67적표체존재정상관관계（ P＜0．05）。결론：연합검측B23화Ki67가능유조우판단궁경암적생존솔，작위림상료효적예후지표。
Objective: To study the expressions of B 23 and Ki67 in cervical carcinoma and evaluate their roles in progonosis .Method:Tissues from 104 cervical carcinoma and 20 normal cervices were obtained with analysis of B 23 and Ki67 expressions by immunohistochemistry .Result:The positive expression rate of B23 in normal cervix and cervical carcinoma was 30.0%and 76.9%respectively (P<0.001), and the posi-tive expression rate of Ki67 in normal cervix and cervical carcinoma was 15.0%and 44.2%respectively (P=0.014).The expressions of B23 and Ki67 were all negatively correlated with progressive-free survial rate of cervical carcinoma .The expression of B 23 was positively correlated with Ki 67 expression .Conclusion: The expression of Ki67 is a significant unfavorable factor of prognosis of cervical squamous cell carcinoma .Com-bined analysis of expressions of B 23 and Ki67 maybe helpful to judge prognosis of cervical carcinoma , and can be a reference factor of the clinical therapy .