CAJ | 학술논문

维生素D受体（ vitamin D receptor， VDR）是调控骨发育、代谢和动态平衡的重要分子，其作用机制涉及遗传基因、信号通路、激素及旁分泌因子等多方面，而VDR信号通路则在其中起到重要的调控作用。虽然针对VDR研制的药物已对骨质疏松疾病的治疗表现出较好效果，但近年来研究发现，通过饮食调节钙和磷的摄取可以纠正VDR缺陷小鼠的骨质损伤表现，该发现对VDR在正常生理状态下骨动态平衡以及骨代谢中的重要性提出了异议。最近有研究提出，VDR的表达主要存在于松质骨未成熟成骨细胞，在其他骨细胞中的表达和功能有待进一步验证。因此，VDR在不同类型骨细胞中的表达及其在骨动态平衡中的作用机制还有待更进一步的研究，有关机理的阐明将为我们深入了解骨质疏松的发病机制奠定基础，从而指导临床相关疾病的治疗。
유생소D수체（ vitamin D receptor， VDR）시조공골발육、대사화동태평형적중요분자，기작용궤제섭급유전기인、신호통로、격소급방분비인자등다방면，이VDR신호통로칙재기중기도중요적조공작용。수연침대VDR연제적약물이대골질소송질병적치료표현출교호효과，단근년래연구발현，통과음식조절개화린적섭취가이규정VDR결함소서적골질손상표현，해발현대VDR재정상생리상태하골동태평형이급골대사중적중요성제출료이의。최근유연구제출，VDR적표체주요존재우송질골미성숙성골세포，재기타골세포중적표체화공능유대진일보험증。인차，VDR재불동류형골세포중적표체급기재골동태평형중적작용궤제환유대경진일보적연구，유관궤리적천명장위아문심입료해골질소송적발병궤제전정기출，종이지도림상상관질병적치료。
Vitamin D receptor ( VDR ) is an important regulator of bone differentiation, metabolism, and homeostasis.The mechanisms include genetic factors, signaling pathway, hormone and paracrine factors, etc.Among them, the VDR signal pathway plays an important role in the processes.The beneficial actions of VDR target agents have been proven in the clinical of osteoporosis treatment.However, it has been defined that the bone phenotype of VDR-deficient mice is rescued when the blood calcium and phosphate levels in the mice are normalized by a special diet.These findings challenge the importance of VDR function in bone homeostasis and metabolism during normal physiology conditions.Recently, the VDR expression has been identified in immature osteoblasts in the cancellous bone.It needs more work to describe the expression and function of VDR in other bone cells.Thus, further study should be performed to reveal the expression and role of VDR in different type of bone cells and bone homeostasis, which can help to find potential pathophysiology and therapeutic ways for osteoporosis and other metabolic bone diseases.