CAJ | 학술논문

目的：本文通过测定我院就诊的老年骨质疏松症患者体内25羟维生素D3水平，分析目前维生素D治疗状况并评价其与季节的关系。方法50例老年骨质疏松症患者（均符合1994年WHO关于骨质疏松症的诊断标准），其中男性28名，平均年龄75．6±1．5岁，女性22名，平均年龄69．3±2．6岁，用放射免疫分析法测定冬夏两季25（ OH） D3、钙、磷、碱性磷酸酶、甲状旁腺素含量。结果所有患者夏季25（OH）D3水平明显高于冬季（男性高42．5％，女性高54．6％，P＜0．05）。维生素D缺乏情况：女性夏季为13．64％，冬季为36．36％，男性夏季为7．14％，冬季35．71％，冬季维生素D缺乏明显高于夏季（ P＜0．05），男女两组钙、磷、碱性磷酸酶、甲状旁腺素含量均在正常范围。结论老年骨质疏松症患者在不同季节存在着不同程度的维生素D缺乏，冬季25（OH）D3水平更低。建议老年人科学合理应用维生素D，应该将定期监测25（OH）D3水平作为骨质疏松症治疗的常规实验室检查，并为临床合理应用维生素D提供科学的理论依据。
목적：본문통과측정아원취진적노년골질소송증환자체내25간유생소D3수평，분석목전유생소D치료상황병평개기여계절적관계。방법50례노년골질소송증환자（균부합1994년WHO관우골질소송증적진단표준），기중남성28명，평균년령75．6±1．5세，녀성22명，평균년령69．3±2．6세，용방사면역분석법측정동하량계25（ OH） D3、개、린、감성린산매、갑상방선소함량。결과소유환자하계25（OH）D3수평명현고우동계（남성고42．5％，녀성고54．6％，P＜0．05）。유생소D결핍정황：녀성하계위13．64％，동계위36．36％，남성하계위7．14％，동계35．71％，동계유생소D결핍명현고우하계（ P＜0．05），남녀량조개、린、감성린산매、갑상방선소함량균재정상범위。결론노년골질소송증환자재불동계절존재착불동정도적유생소D결핍，동계25（OH）D3수평경저。건의노년인과학합리응용유생소D，응해장정기감측25（OH）D3수평작위골질소송증치료적상규실험실검사，병위림상합리응용유생소D제공과학적이론의거。
Objective This study aims to analyze the current clinic treatment using vitamin D for osteoporosis and its relationship with season via measuring the 25-hydroxyvitamin D3 [25(OH)D3] level in senile patients with osteoporosis.Methods Fifty cases of senile osteoporosis were included in this study (in accordance with the WHO diagnostic criteria for osteoporosis, 1994), in which 28 were males with mean age of 75.6 ±1.5 years, and 22 were females with mean age of 69.3 ±2.6 years. Radioimmunoassay was applied to determine the serum 25 ( OH ) D3 level in summer and winter, respectively.The content of calcium, phosphorus, alkaline phosphatase, and parathyroid hormone were also measured.Results Among all of the patients, the serum 25(OH)D3 levels in summer were significantly higher than those in winter (males:42.5%higher, females:54.6%higher, P<0.05 ) .The vitamin D deficiency situation was 13.64% of women in summer and 36.36% in winter, 7.14% of men in summer and 35.71% in winter, respectively.Significantly high vitamin D deficiency happened in winter comparing with that in summer ( P <0.05 ) .The serum calcium, phosphorus, alkaline phosphatase, and parathyroid hormone levels were within the normal range in two groups.Conclusion There are different degrees of vitamin D deficiency in elderly patients with osteoporosis in different seasons.The serum 25(OH)D3 levels in winter were lower.It is recommended of scientific and rational application of vitamin D among the elderly.The serum 25(OH)D3 levels should be regularly monitored as routine laboratory test for osteoporosis treatment, which may provide theoretical basis for reasonable clinical application of vitamin D in the treatment of senile osteoporosis.