河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
1期
118-122
,共5页
喉癌%水通道蛋白-1%临床病理特征
喉癌%水通道蛋白-1%臨床病理特徵
후암%수통도단백-1%림상병리특정
Laryngeal carcinoma%Aquaporins-1%Clinicopathological characteristics
目的：探讨血清水通道蛋1（AQP1）在喉癌中的表达及其与喉癌临床病理特征的关系。方法：采用酶联免疫吸附法（ ELISA）检测82例喉癌患者（喉癌组）和30例健康者（对照组）的AQP1的水平，并结合患者的TNM分期（0期、Ⅰ期、Ⅱ期、Ⅲ期及Ⅳ期）、肿瘤组织学分化程度（高分化、中分化和低分化）、浸润深度（ T1、T2、T3、T4期）及淋巴结转（ N0、N1及N2）情况进行分析。结果：喉癌血清AQP1水平比健康对照组显著增加（ P＜0．05）；除了浸润深度T1、T2之间无统计学差异（ P＞0．05），其他不同TNM分期、肿瘤组织学分化程度、浸润深度、淋巴结转患者的血清AQP 1水平两两之间差异均有统计学意义（均为P＜0．05）；喉癌患者AQP1与TMN分期、浸润深度、淋巴结转移具有正相关性（均为P＜0．05）；与肿瘤组织学分化程度具有负相关性（ P＜0．05）。结论：喉癌患者血清AQP1水平升高，并且与TMN分期、浸润深度、淋巴结转移及肿瘤组织学分化有关系，有望作为喉癌早期诊断的血清分子标记物。
目的：探討血清水通道蛋1（AQP1）在喉癌中的錶達及其與喉癌臨床病理特徵的關繫。方法：採用酶聯免疫吸附法（ ELISA）檢測82例喉癌患者（喉癌組）和30例健康者（對照組）的AQP1的水平，併結閤患者的TNM分期（0期、Ⅰ期、Ⅱ期、Ⅲ期及Ⅳ期）、腫瘤組織學分化程度（高分化、中分化和低分化）、浸潤深度（ T1、T2、T3、T4期）及淋巴結轉（ N0、N1及N2）情況進行分析。結果：喉癌血清AQP1水平比健康對照組顯著增加（ P＜0．05）；除瞭浸潤深度T1、T2之間無統計學差異（ P＞0．05），其他不同TNM分期、腫瘤組織學分化程度、浸潤深度、淋巴結轉患者的血清AQP 1水平兩兩之間差異均有統計學意義（均為P＜0．05）；喉癌患者AQP1與TMN分期、浸潤深度、淋巴結轉移具有正相關性（均為P＜0．05）；與腫瘤組織學分化程度具有負相關性（ P＜0．05）。結論：喉癌患者血清AQP1水平升高，併且與TMN分期、浸潤深度、淋巴結轉移及腫瘤組織學分化有關繫，有望作為喉癌早期診斷的血清分子標記物。
목적：탐토혈청수통도단1（AQP1）재후암중적표체급기여후암림상병리특정적관계。방법：채용매련면역흡부법（ ELISA）검측82례후암환자（후암조）화30례건강자（대조조）적AQP1적수평，병결합환자적TNM분기（0기、Ⅰ기、Ⅱ기、Ⅲ기급Ⅳ기）、종류조직학분화정도（고분화、중분화화저분화）、침윤심도（ T1、T2、T3、T4기）급림파결전（ N0、N1급N2）정황진행분석。결과：후암혈청AQP1수평비건강대조조현저증가（ P＜0．05）；제료침윤심도T1、T2지간무통계학차이（ P＞0．05），기타불동TNM분기、종류조직학분화정도、침윤심도、림파결전환자적혈청AQP 1수평량량지간차이균유통계학의의（균위P＜0．05）；후암환자AQP1여TMN분기、침윤심도、림파결전이구유정상관성（균위P＜0．05）；여종류조직학분화정도구유부상관성（ P＜0．05）。결론：후암환자혈청AQP1수평승고，병차여TMN분기、침윤심도、림파결전이급종류조직학분화유관계，유망작위후암조기진단적혈청분자표기물。
Objective:To explore the expression of serum aquaporins-1( AQP-1) and the relationship with clinicopathological characteristics in patients with laryngeal carcinoma .Method: The levels of serum aquaporins-1 detected by enzyme-linked immunosorbent assay (ELISA)in 89 patients with laryngeal carci-noma ( laryngeal carcinoma group ) and 30 healthy subjects ( control group ) ,and the TNM staging ( stage 0, stageⅠ, stageⅡ, stageⅢand stageⅣ) , the degree of tumor differentiation ( poor differentiated , moderately differentiated and well differentiated ) , infiltrating depth ( T1, T2, T3, T4) and lymph node metastasis ( N0, N1, and N2) were analyzed.Result:The levels of serum AQP-1 in laryngeal carcinoma group were signifi-cantly elevated,compared with healthy control group (P <0.05), the levels of serum AQP-1 in any two in TNM Staging tumor differentiation , infiltrating depth and lymph node metastasis were very signifficant differ-ence ( P<0.05) ,except T1 and T2( P>0.05) , the levels of serum AQP-1in patients with laryngeal carcino-ma was a positive correlation with TNM staging infiltrating depth or lymph node metastasis ( P <0.05) .The levels of serum AQP-1in patients with laryngeal carcinoma was negative correlation with tumor differentiation (P <0.05).Conclusion: The levels of serum AQP-1 in patients with laryngeal is increased.There's rela-tionship between serum AQP-1 and TNM staging , infiltrating depth , tumor differentiation or lymph node me-tastasis, The serum AQP-1 levels is expected to become the new serum tumor markers in early diagnosis of laryngeal cancer .
