CAJ | 학술논문

白细胞介素17C是不同于其他白细胞介素17家族的新型细胞因子,是一种来源于上皮细胞的多功能细胞因子,在多种病原感染和炎症反应中检测出优先诱导性的表达,主要通过与其高亲和性受体特异性结合,经自分泌方式作用于靶细胞或与其他细胞因子相互作用诱导相关抗菌肽、促炎症性细胞因子和趋化因子等的表达,参与了包括银屑病在内的多种上皮源性疾病的发生,可能在疾病的发病机制中起重要作用.
백세포개소17C시불동우기타백세포개소17가족적신형세포인자,시일충래원우상피세포적다공능세포인자,재다충병원감염화염증반응중검측출우선유도성적표체,주요통과여기고친화성수체특이성결합,경자분비방식작용우파세포혹여기타세포인자상호작용유도상관항균태、촉염증성세포인자화추화인자등적표체,삼여료포괄은설병재내적다충상피원성질병적발생,가능재질병적발병궤제중기중요작용.
Interleukin (IL)-17C,a multifunctional cytokine derived from epithelial cells,is different from the other IL-17 family members.There is a preferential and inductive expression of IL-17C in multiple infections and inflammatory reactions.By specifically binding to its high-affinity receptor,IL-17C can act on target cells or interact on other cytokines in an autocrine manner,induce the expressions of antimicrobial peptides,pro-inflammatory cytokines and chemokines.It is involved in the initiation of multiple diseases of epithelial origin (including psoriasis),and may play an important role in their pathogenesis.The authors review the biological function of IL-17C and its relationship with psoriasis.