CAJ | 학술논문

目的：研究血清和肽素（ COP）和血清淀粉样蛋白A（ SAA）水平在扩张型心肌病（ DCM）与缺血性心肌病（ ICM）中的鉴别价值及其与心衰严重程度之间的关系。方法入选对象65例，结合临床表现、心脏超声、BNP和部分患者冠脉造影检查随机分为：扩张型心肌病患者30例（ A组）、缺血性心肌病患者35例（ B组）、同期健康志愿者20例作为对照组（ C组）。测定各组的COP及SAA水平，进行对比观察。结果 A，B两组的血清COP和SAA水平明显高于C组，差异有显著性（P＜0．05）。 A组血清SAA水平高于B组（P＜0．05），A，B组COP水平差异无明显统计学意义（t＝0．452，P＞0．05）。 A，B两组中按NYHA分级分成的各亚组的血清COP水平随心衰程度加重而升高（F值分别为13．7，9．9，P＜0．05），而血清SAA水平却没有这种随心功能分级升高而递增趋势。结论血清SAA水平对扩张型心肌病与缺血性心肌病具有鉴别诊断意义，血清COP水平可以用于评估心衰的程度，成为评价心衰的一个新指标。
목적：연구혈청화태소（ COP）화혈청정분양단백A（ SAA）수평재확장형심기병（ DCM）여결혈성심기병（ ICM）중적감별개치급기여심쇠엄중정도지간적관계。방법입선대상65례，결합림상표현、심장초성、BNP화부분환자관맥조영검사수궤분위：확장형심기병환자30례（ A조）、결혈성심기병환자35례（ B조）、동기건강지원자20례작위대조조（ C조）。측정각조적COP급SAA수평，진행대비관찰。결과 A，B량조적혈청COP화SAA수평명현고우C조，차이유현저성（P＜0．05）。 A조혈청SAA수평고우B조（P＜0．05），A，B조COP수평차이무명현통계학의의（t＝0．452，P＞0．05）。 A，B량조중안NYHA분급분성적각아조적혈청COP수평수심쇠정도가중이승고（F치분별위13．7，9．9，P＜0．05），이혈청SAA수평각몰유저충수심공능분급승고이체증추세。결론혈청SAA수평대확장형심기병여결혈성심기병구유감별진단의의，혈청COP수평가이용우평고심쇠적정도，성위평개심쇠적일개신지표。
[ ABSTRACT] Objective To study the value of copeptin( COP) and SAA in distinguishing DCM and ICM and the relationship between the COP and SAA levels and the severity of heart failure.Methods 65 patients were divided into two groups according to the clinical manifestations,cardiac ultrasound and CAG( group A,30 patients with DCM;group B,35 patients with ICM ) ,another 20 healthy people as group C.The level of COP and SAA in each group were examined and compared.Results The level of COP and SAA in group A and B were much higher than that in group C (P<0.05).Compared with group B SAA in group A were higher(P<0.05),but the difference of the level of COP be-tween group A and group B was not significant.The level of COP rised with worsening heart faiure in group A and B( F were 13.7 and 9.9,P<0.05),neither did SAA.Conclusion The level of SAA is valueable in the differential diagnosis between DCM and ICM.The level of COP can be viewed as a new assessment indicator of heart failure.