CAJ | 학술논문

目的：观察糖尿病大鼠早期视觉电生理改变及生长抑素的水平动态变化。方法：将30只大鼠随机分为正常对照组和糖尿病实验组。腹腔注射链脲佐菌素诱导建立糖尿病大鼠模型。分别测定两组大鼠的视网膜电图改变及生长抑素的变化，并对各指标进行统计学分析。结果：成功建立大鼠糖尿病模型。建模后1周糖尿病组杆细胞反应及最大反应的a波和b波的潜伏期都比对照组显著延长，差异有统计学意义（P<0.05），但振幅无改变，生长抑素水平下降，差异有统计学意义（P<0.05）。建模后6周时糖尿病组除潜伏期持续延长外，振幅也开始下降，差异有统计学意义（ P<0.05）。结论：糖尿病大鼠早期即出现杆细胞反应及最大反应的a波和b波的潜伏期显著延，振幅明显下降，生长抑素水平亦明显下降。
목적：관찰당뇨병대서조기시각전생리개변급생장억소적수평동태변화。방법：장30지대서수궤분위정상대조조화당뇨병실험조。복강주사련뇨좌균소유도건립당뇨병대서모형。분별측정량조대서적시망막전도개변급생장억소적변화，병대각지표진행통계학분석。결과：성공건립대서당뇨병모형。건모후1주당뇨병조간세포반응급최대반응적a파화b파적잠복기도비대조조현저연장，차이유통계학의의（P<0.05），단진폭무개변，생장억소수평하강，차이유통계학의의（P<0.05）。건모후6주시당뇨병조제잠복기지속연장외，진폭야개시하강，차이유통계학의의（ P<0.05）。결론：당뇨병대서조기즉출현간세포반응급최대반응적a파화b파적잠복기현저연，진폭명현하강，생장억소수평역명현하강。
Objective To observe the changes of electroretinogram and serum somatostatin in STZ-induced diabetic rats. Method 30 rats were randomly divided into two groups of normal contrast and diabetes mellitus. Wistar rats were injected intraperitoneally with strepto-zocin( STZ,55 mg/kg body weight)once to induce models of diabetes. The changes of electroretinogram and plasma somatostatin in two groups were observed and analyzed. Results The rat diabetic model was well established. One week after modeling,latent period and ampli-tude of a-wave,b-wave of rod-response and max-response in diabetic group were significantly longer than the control group,the differ-ence was statistically significant( P<0. 05),but amplitude of a-wave and b-wave didn't change. Somatostatin levels declined,the differ-ence was statistically significant. Six weeks after modeling,these amplitudes started to decline in diabetic group,the difference was statisti-cally significant(P<0. 05). Conclusion Early diabetic rats appears rod cell response and maximum response latency of a wave and b-wave is significantly extended,the amplitude decreases,somatostatin levels also decreases significantly( P<0. 05).