中华实验和临床感染病杂志（电子版）
中華實驗和臨床感染病雜誌（電子版）
중화실험화림상감염병잡지（전자판）
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2014年
5期
658-660
,共3页
C-反应蛋白%血清降钙素原%感染
C-反應蛋白%血清降鈣素原%感染
C-반응단백%혈청강개소원%감염
C-reactive protein%Procalcitonin%Infection
目的：探讨C-反应蛋白（CRP）和血清降钙素原（PCT）对危重患者感染的监测价值。方法收集2012年10月至2013年10月本院ICU病房收治的98例危重患者，根据辅助检查结果将其分为细菌感染组（68例）和病毒感染组（30例）两组，对其PCT和CRP含量进行测定。并将细菌感染组患者随机分为观察组和对照组，每组各34例；动态监测其治疗前后PCT和CRP含量的变化情况。结果细菌感染组和病毒感染组患者的PCT平均含量分别为（3.64±0.58）μg/L和（0.37±0.35）μg/L，差异具有统计学意义（t=2.437，P ＜0.05）。细菌感染组和病毒感染组患者的CRP平均含量分别为（38.27±20.55）mg/L和（37.91±20.63 mg/L）相比，差异无统计学意义（t=0.694，P＞0.05）。观察组治疗后PCT的平均含量由治疗前的（3.68±0.62）μg/L下降为（0.53±0.21）μg/L，相比于对照组由治疗前的（3.59±0.51）μg/L下降为（2.67±0.43）μg/L，下降幅度更大；观察组治疗后CRP的平均含量为（13.81±5.64）mg/L，显著低于对照组的（21.53±5.38）mg/L，差异具有统计学意义（t=5.724，P＜0.05）。结论 PCT和CRP含量的动态监测在临床应用时各有优势，二者联合应用，在对危重患者感染的诊断和治疗中具有极高的临床价值。
目的：探討C-反應蛋白（CRP）和血清降鈣素原（PCT）對危重患者感染的鑑測價值。方法收集2012年10月至2013年10月本院ICU病房收治的98例危重患者，根據輔助檢查結果將其分為細菌感染組（68例）和病毒感染組（30例）兩組，對其PCT和CRP含量進行測定。併將細菌感染組患者隨機分為觀察組和對照組，每組各34例；動態鑑測其治療前後PCT和CRP含量的變化情況。結果細菌感染組和病毒感染組患者的PCT平均含量分彆為（3.64±0.58）μg/L和（0.37±0.35）μg/L，差異具有統計學意義（t=2.437，P ＜0.05）。細菌感染組和病毒感染組患者的CRP平均含量分彆為（38.27±20.55）mg/L和（37.91±20.63 mg/L）相比，差異無統計學意義（t=0.694，P＞0.05）。觀察組治療後PCT的平均含量由治療前的（3.68±0.62）μg/L下降為（0.53±0.21）μg/L，相比于對照組由治療前的（3.59±0.51）μg/L下降為（2.67±0.43）μg/L，下降幅度更大；觀察組治療後CRP的平均含量為（13.81±5.64）mg/L，顯著低于對照組的（21.53±5.38）mg/L，差異具有統計學意義（t=5.724，P＜0.05）。結論 PCT和CRP含量的動態鑑測在臨床應用時各有優勢，二者聯閤應用，在對危重患者感染的診斷和治療中具有極高的臨床價值。
목적：탐토C-반응단백（CRP）화혈청강개소원（PCT）대위중환자감염적감측개치。방법수집2012년10월지2013년10월본원ICU병방수치적98례위중환자，근거보조검사결과장기분위세균감염조（68례）화병독감염조（30례）량조，대기PCT화CRP함량진행측정。병장세균감염조환자수궤분위관찰조화대조조，매조각34례；동태감측기치료전후PCT화CRP함량적변화정황。결과세균감염조화병독감염조환자적PCT평균함량분별위（3.64±0.58）μg/L화（0.37±0.35）μg/L，차이구유통계학의의（t=2.437，P ＜0.05）。세균감염조화병독감염조환자적CRP평균함량분별위（38.27±20.55）mg/L화（37.91±20.63 mg/L）상비，차이무통계학의의（t=0.694，P＞0.05）。관찰조치료후PCT적평균함량유치료전적（3.68±0.62）μg/L하강위（0.53±0.21）μg/L，상비우대조조유치료전적（3.59±0.51）μg/L하강위（2.67±0.43）μg/L，하강폭도경대；관찰조치료후CRP적평균함량위（13.81±5.64）mg/L，현저저우대조조적（21.53±5.38）mg/L，차이구유통계학의의（t=5.724，P＜0.05）。결론 PCT화CRP함량적동태감측재림상응용시각유우세，이자연합응용，재대위중환자감염적진단화치료중구유겁고적림상개치。
Objective To investigate the value of C-reactive protein (CRP) and procalcitonin (PCT) monitoring of critically ill patients infection. Methods Total of 98 critically ill patients with infection were collected from October 2012 to October 2013 in ICU ward of our hospital, Those patients were divided into bacterial infection group (68 cases) and viral infection group (30 cases) according to results of laboratory examinations. The levels of PCT and CRP were measured in the two groups, respectively. And the 68 patients with bacterial infections were randomly divided into observation group and control group, with 34 cases in each group;while the changes of PCT and CRP of the two groups were dynamic monitored before and after treatment. Results The average content of PCT in patients with bacterial infection and viral infection were (3.64 ± 0.58)μg/L and (0.37 ± 0.35)μg/L, respectively, with signiifcant difference (t=2.437,P<0.05). The average evels of CRP in patients with bacterial infection and viral infection were (38.27 ± 20.55) mg/L and (37.91 ± 20.63) mg/L, with no signiifcant difference (t=0.694,P>0.05). After treatment, the average content of the PCT in observation group decreased to (0.53 ± 0.21)μg/L from (3.68 ± 0.62)μg/L, while in the control group the average content of the PCT decreased to (2.67 ± 0.43)μg/L from (3.59 ± 0.51)μg/L, compared with the control group, the content of the PCT in observation group decreased signiifcantly. After treatment, the mean content of CRP was (13.81 ± 5.64) mg/L, signiifcantly lower than the control group that with (21.53 ± 5.38) mg/L (t=5.724,P<0.05). Conclusions Monitoring of the contents of PCT and CRP in clinical applications have their own advantages, and it has high clinical value of joint application with the two indexes both in the diagnosis and treatment of infection in patients with critically ill.
