中华实验和临床感染病杂志（电子版）
中華實驗和臨床感染病雜誌（電子版）
중화실험화림상감염병잡지（전자판）
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2014年
5期
605-608
,共4页
肝硬化%自发性腹膜炎
肝硬化%自髮性腹膜炎
간경화%자발성복막염
Liver cirrhosis%Spontaneous bacterial peritonitis
目的：探讨肝硬化腹水并发自发性细菌性腹膜炎（SBP）的危险因素。方法选择40例肝硬化腹水并发SBP和28例未并发SBP的肝硬化腹水患者作为研究对象，采取回顾性研究的方法对相关临床资料进行分析。结果肝硬化腹水并发SBP者在并发休克、肝肾综合征、原发性肝癌、上消化道出血以及年龄区间、多次住院、既往是否发生腹水等方面与不合并SBP患者差异具有统计学意义（P均＜0.05）；两组患者的外周血TBil、ALB、PT、CR、UA以及血钠表达水平差异具有统计学意义（P均＜0.05）。患者年龄、TBil、ALB、PT、血钠和CR作为可作为单因素预测肝硬化腹水并发SBP发生（P均＜0.05）。多因素Logistic回归分析结果发现，TBil、ALB以及是否合并原发性肝癌两组间差异具有统计学意义（P均＜0.05）。结论高胆红素血症、低蛋白血症以及合并原发性肝癌为肝硬化腹水患者并发SBP的危险因素，对这类患者应及时预防性使用抗菌药物。
目的：探討肝硬化腹水併髮自髮性細菌性腹膜炎（SBP）的危險因素。方法選擇40例肝硬化腹水併髮SBP和28例未併髮SBP的肝硬化腹水患者作為研究對象，採取迴顧性研究的方法對相關臨床資料進行分析。結果肝硬化腹水併髮SBP者在併髮休剋、肝腎綜閤徵、原髮性肝癌、上消化道齣血以及年齡區間、多次住院、既往是否髮生腹水等方麵與不閤併SBP患者差異具有統計學意義（P均＜0.05）；兩組患者的外週血TBil、ALB、PT、CR、UA以及血鈉錶達水平差異具有統計學意義（P均＜0.05）。患者年齡、TBil、ALB、PT、血鈉和CR作為可作為單因素預測肝硬化腹水併髮SBP髮生（P均＜0.05）。多因素Logistic迴歸分析結果髮現，TBil、ALB以及是否閤併原髮性肝癌兩組間差異具有統計學意義（P均＜0.05）。結論高膽紅素血癥、低蛋白血癥以及閤併原髮性肝癌為肝硬化腹水患者併髮SBP的危險因素，對這類患者應及時預防性使用抗菌藥物。
목적：탐토간경화복수병발자발성세균성복막염（SBP）적위험인소。방법선택40례간경화복수병발SBP화28례미병발SBP적간경화복수환자작위연구대상，채취회고성연구적방법대상관림상자료진행분석。결과간경화복수병발SBP자재병발휴극、간신종합정、원발성간암、상소화도출혈이급년령구간、다차주원、기왕시부발생복수등방면여불합병SBP환자차이구유통계학의의（P균＜0.05）；량조환자적외주혈TBil、ALB、PT、CR、UA이급혈납표체수평차이구유통계학의의（P균＜0.05）。환자년령、TBil、ALB、PT、혈납화CR작위가작위단인소예측간경화복수병발SBP발생（P균＜0.05）。다인소Logistic회귀분석결과발현，TBil、ALB이급시부합병원발성간암량조간차이구유통계학의의（P균＜0.05）。결론고담홍소혈증、저단백혈증이급합병원발성간암위간경화복수환자병발SBP적위험인소，대저류환자응급시예방성사용항균약물。
[Abastract]Objective To investigate the risk factors of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites. Methods Total of 40 patients with SBP and 28 no-SBP in cirrhotic patients with ascites were collected, respectively. The clinical data were analyzed, retrospectively. Results The incidence of shock, hepatorenal syndrome, primary liver cancer, upper gastrointestinal bleeding, several times being hospitalized, previous ascites were signiifcantly different between in SBP and non-SBP in cirrhotic patients with ascites (P all < 0.05). The distribution of age, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), albumin (ALB), creatinine (CR), prothrombin time (PT) and serum sodium between the two groups were all with signiifcant differences (P all<0.05). The age, TBil, ALB, PT, serum sodium, CR and hepatorenal syndrome, primary liver caner, upper gastrointestinal bleeding and several times being hospitalized were the risk factors for SBP in cirrhotic patients with acites, tested by univariate analysis (P all < 0.05). But if multivariate Logistic regression analysis results showed only TBil, ALB and the incidence of primary liver cancer were difference between SBP and non-SBP in cirrhosis patients with ascites (P all<0.05). Conclusions Hyerbilirubinemia, hyporotinemia and the incidence of primary liver cancer were the risk factors of SBP in cirrhotic patients with ascites. If patients had these factors, antibiotic prophylaxis should be given.
