中国中西医结合急救杂志
中國中西醫結閤急救雜誌
중국중서의결합급구잡지
INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE IN PRACTICE OF CRITICAL CARE MEDICINE
2014年
6期
439-441
,共3页
喘息性支气管炎%小儿%丹参注射液%呼出气一氧化氮%中西医结合疗法
喘息性支氣管炎%小兒%丹參註射液%呼齣氣一氧化氮%中西醫結閤療法
천식성지기관염%소인%단삼주사액%호출기일양화담%중서의결합요법
Asthmatic bronchitis%Child%Danshen injection%Exhaled nitric oxide content%Integrative Chinese and western medicine treatment
目的：探讨丹参注射液联合常规治疗对小儿喘息性支气管炎反复发作的临床疗效。方法采用前瞻性研究方法，选择2012年1月至2014年7月河南省人民医院收治的喘息性支气管炎患儿55例，按随机原则分为中西医结合治疗组30例和常规治疗组25例；同期选取本院健康体检小儿18例为健康对照组。常规治疗组给予休息、吸氧、抗感染、补液、雾化吸入等常规治疗；中西医结合治疗组在常规治疗基础上加用丹参注射液0.4 mL · kg-1· d-1，每日1次，共14 d。观察常规治疗组和中西医结合治疗组患者喘息缓解时间和肺部啰音消失时间，并观察3组受试者呼出气一氧化氮（FeNO）水平。结果中西医结合治疗组喘息缓解时间及肺部啰音消失时间均较常规治疗组明显缩短〔喘息缓解时间（d）：2.3±0.8比5.2±1.1，肺部啰音消失时间（d）：6.8±1.5比8.4±1.1，均P＜0.01〕。中西医结合治疗组及常规治疗组治疗前FeNO均明显高于健康对照组（×10-9：30.3±9.5、30.4±8.2比13.6±3.4，均P＜0.01），治疗后中西医结合治疗组和常规治疗组FeNO均明显降低，且以中西医结合治疗组变化更显著（×10-9：18.6±4.7比24.0±6.8，P＜0.01）。结论丹参注射液结合常规治疗可显著下调FeNO，从而减轻气道炎症，有效地缓解喘息性支气管炎的发作。
目的：探討丹參註射液聯閤常規治療對小兒喘息性支氣管炎反複髮作的臨床療效。方法採用前瞻性研究方法，選擇2012年1月至2014年7月河南省人民醫院收治的喘息性支氣管炎患兒55例，按隨機原則分為中西醫結閤治療組30例和常規治療組25例；同期選取本院健康體檢小兒18例為健康對照組。常規治療組給予休息、吸氧、抗感染、補液、霧化吸入等常規治療；中西醫結閤治療組在常規治療基礎上加用丹參註射液0.4 mL · kg-1· d-1，每日1次，共14 d。觀察常規治療組和中西醫結閤治療組患者喘息緩解時間和肺部啰音消失時間，併觀察3組受試者呼齣氣一氧化氮（FeNO）水平。結果中西醫結閤治療組喘息緩解時間及肺部啰音消失時間均較常規治療組明顯縮短〔喘息緩解時間（d）：2.3±0.8比5.2±1.1，肺部啰音消失時間（d）：6.8±1.5比8.4±1.1，均P＜0.01〕。中西醫結閤治療組及常規治療組治療前FeNO均明顯高于健康對照組（×10-9：30.3±9.5、30.4±8.2比13.6±3.4，均P＜0.01），治療後中西醫結閤治療組和常規治療組FeNO均明顯降低，且以中西醫結閤治療組變化更顯著（×10-9：18.6±4.7比24.0±6.8，P＜0.01）。結論丹參註射液結閤常規治療可顯著下調FeNO，從而減輕氣道炎癥，有效地緩解喘息性支氣管炎的髮作。
목적：탐토단삼주사액연합상규치료대소인천식성지기관염반복발작적림상료효。방법채용전첨성연구방법，선택2012년1월지2014년7월하남성인민의원수치적천식성지기관염환인55례，안수궤원칙분위중서의결합치료조30례화상규치료조25례；동기선취본원건강체검소인18례위건강대조조。상규치료조급여휴식、흡양、항감염、보액、무화흡입등상규치료；중서의결합치료조재상규치료기출상가용단삼주사액0.4 mL · kg-1· d-1，매일1차，공14 d。관찰상규치료조화중서의결합치료조환자천식완해시간화폐부라음소실시간，병관찰3조수시자호출기일양화담（FeNO）수평。결과중서의결합치료조천식완해시간급폐부라음소실시간균교상규치료조명현축단〔천식완해시간（d）：2.3±0.8비5.2±1.1，폐부라음소실시간（d）：6.8±1.5비8.4±1.1，균P＜0.01〕。중서의결합치료조급상규치료조치료전FeNO균명현고우건강대조조（×10-9：30.3±9.5、30.4±8.2비13.6±3.4，균P＜0.01），치료후중서의결합치료조화상규치료조FeNO균명현강저，차이중서의결합치료조변화경현저（×10-9：18.6±4.7비24.0±6.8，P＜0.01）。결론단삼주사액결합상규치료가현저하조FeNO，종이감경기도염증，유효지완해천식성지기관염적발작。
Objective To study the therapeutic effect of Danshen injection combined with conventional therapy on children with recurrent asthmatic bronchitis. Methods A prospective study was conducted. Fifty-five children with asthmatic bronchitis admitted in People's Hospital of Henan Province from January 2012 to July 2014 were enrolled and randomly divided into a integrative Chinese and western medicine group(30 cases)and a conventional therapy group(25 cases);in the same period,18 healthy children having passed physical examinations were chosen as the healthy control group. In the conventional therapy group,rest,oxygen inspiration,anti-infection, fluid supplement and aerosol inhalation,etc. were given,while in the integrative Chinese and western medicine group,based on the similar conventional therapies,additionally Danshen injection 0.4 mL · kg-1 · d-1 was given,once per day for a total of 14 days. The wheezing remission time and the pulmonary rale extinction time were observed in the two patient groups,and the fractional exhaled nitric oxide(FeNO)content was investigated in the three groups. Results The wheezing remission time and the pulmonary rale extinction time of the integrative Chinese and western medicine group were obviously shortened compared with those in the conventional therapy group〔the wheezing remission time(days):2.3±0.8 vs. 5.2±1.1,the pulmonary rale extinction time(days):6.8±1.5 vs. 8.4±1.1,both P<0.01〕. The contents of FeNO in the integrative Chinese and western medicine group and the conventional therapy group before treatment were significantly higher than those in the healthy control group(×10-9:30.3±9.5,30.4±8.2 vs. 13.6±3.4,both P<0.01),but after treatment the FeNO levels of both patient groups were markedly lowered,and the degree of change in integrative Chinese and western medicine group was more significant(×10-9:18.6±4.7 vs. 24.0±6.8,P<0.01). Conclusion Danshen injection combined with conventional therapy can obviously down-regulate the FeNO content,alleviate the airway inflammation,effectively relieve the children recurrence of asthmatic bronchitis.
