CAJ | 학술논문

目的：探讨老年高血压患者血清胱抑素 C（Cys C）水平变化与左室舒张功能的关系。方法回顾性分析老年高血压患者66例，依据其舒张功能分为正常组和减退组。采用乳胶免疫比浊法检测 Cys C，彩色多普勒超声仪测量左室收缩及舒张功能参数，同时采集患者基础情况及血脂、血肌酐、尿素氮、尿酸等资料。结果和舒张功能正常组相比，舒张功能减退组患者 Cys C 升高，差异有统计学意义（P ＜0．05）；肌酐、尿酸、尿素氮水平差异无统计学意义（P ＞0．05）。Cys C 与左心室射血分数（LVEF）呈中度负相关（r ＝－0．617，P ＜0．05）；以肌酐为控制变量的偏相关分析，Cys C 与 LVEF 仍呈中度负相关（r ＝－0．591，P ＜0．05）。结论血清 Cys C 升高可能是老年高血压患者发生心功能不全的有效预测因子。
목적：탐토노년고혈압환자혈청광억소 C（Cys C）수평변화여좌실서장공능적관계。방법회고성분석노년고혈압환자66례，의거기서장공능분위정상조화감퇴조。채용유효면역비탁법검측 Cys C，채색다보륵초성의측량좌실수축급서장공능삼수，동시채집환자기출정황급혈지、혈기항、뇨소담、뇨산등자료。결과화서장공능정상조상비，서장공능감퇴조환자 Cys C 승고，차이유통계학의의（P ＜0．05）；기항、뇨산、뇨소담수평차이무통계학의의（P ＞0．05）。Cys C 여좌심실사혈분수（LVEF）정중도부상관（r ＝－0．617，P ＜0．05）；이기항위공제변량적편상관분석，Cys C 여 LVEF 잉정중도부상관（r ＝－0．591，P ＜0．05）。결론혈청 Cys C 승고가능시노년고혈압환자발생심공능불전적유효예측인자。
Objective To investigate the relationship between serum cystatin C (Cys C)and left ventricular diastolic function in elderly patients with hypertension.Methods Retrospective analysis was performed in 66 cases of elderly patients with hypertension,who were divided into normal diastolic function group and diastolic dysfunction group.Serum levels of Cys C were detected by latex-enhanced immunoturbidimetric assay;the parameters of left ven-tricular systolic and diastolic function were measured by color doppler.The data such as the levels of lipids,creati-nine,urea nitrogen,uric acid and other information were also collected.Results Compared with the normal diastolic function group,the levels of serum Cys C were higher than that in diastolic dysfunction group(P <0.05);the levels of serum creatinine,uric acid and urea nitrogen had no significant difference between two groups(P >0.05).There was negative correlation between the level of Cys C and left ventricular ejection fraction (LVEF)(r =-0.61 7,P <0.05);after controlled by creatinine,the partial correlation coefficient was -0.591 (P <0.05).Conclusions In-creased serum Cys C may be an value predictor of heart dysfunction in the elderly patients with hypertension.