CAJ | 학술논문

目的：探讨谷氨酰胺与无乳糖配方奶喂养对坏死性小肠结肠炎早产儿营养状态、免疫功能及胃肠激素的影响。方法将坏死性小肠结肠炎早产儿60例纳入研究对象，采用随机数字表法分为观察组和对照组各30例，观察组患儿接受谷氨酰胺与无乳糖配方奶喂养，对照组患儿接受谷氨酰胺与母乳喂养，比较2组患儿的营养状态、免疫功能、胃肠道激素水平。结果（1）营养状态：治疗后4周比较，观察组患儿白蛋白、前蛋白含量均明显高于对照组[（112?．31±15．23） g／L vs．（103．19±13．75） g／L，（41．48±5．61） g／L vs．（32．58±4．46） g／L， P均＜0．05]；（2）免疫功能：治疗后2周比较，观察组患者的CD4＋T细胞以及IgA、IgG、IgM含量均高于对照组[（38．11±3．91）％ vs．（32．52±4．84）％，（13．14±1．45） g／L vs．（10．12±0．73） g／L，（2．86±0．33） g／L vs．（1．77±0．21） g／L，（1．43±0．19） g／L vs．（1．02±0．13） g／L， P均＜0．05]，CD8＋T细胞明显低于对照组[（21．95±3．13）％ vs．（27．51± 3．76）％， P均＜0．05]；（3）胃肠道激素：观察组患儿胃泌素和胃动素含量均明显高于对照组[（292．45±35．82） pg／ml vs．（231．38±29．14） pg／ml，（121．85±16．34） pg／ml vs．（90．45±11．34） pg／ml， P均＜0．05]。结论谷氨酰胺与无乳糖配方奶喂养有助于改善营养状态、免疫功能，提高胃肠道激素含量，从而提高治疗效果。
목적：탐토곡안선알여무유당배방내위양대배사성소장결장염조산인영양상태、면역공능급위장격소적영향。방법장배사성소장결장염조산인60례납입연구대상，채용수궤수자표법분위관찰조화대조조각30례，관찰조환인접수곡안선알여무유당배방내위양，대조조환인접수곡안선알여모유위양，비교2조환인적영양상태、면역공능、위장도격소수평。결과（1）영양상태：치료후4주비교，관찰조환인백단백、전단백함량균명현고우대조조[（112?．31±15．23） g／L vs．（103．19±13．75） g／L，（41．48±5．61） g／L vs．（32．58±4．46） g／L， P균＜0．05]；（2）면역공능：치료후2주비교，관찰조환자적CD4＋T세포이급IgA、IgG、IgM함량균고우대조조[（38．11±3．91）％ vs．（32．52±4．84）％，（13．14±1．45） g／L vs．（10．12±0．73） g／L，（2．86±0．33） g／L vs．（1．77±0．21） g／L，（1．43±0．19） g／L vs．（1．02±0．13） g／L， P균＜0．05]，CD8＋T세포명현저우대조조[（21．95±3．13）％ vs．（27．51± 3．76）％， P균＜0．05]；（3）위장도격소：관찰조환인위비소화위동소함량균명현고우대조조[（292．45±35．82） pg／ml vs．（231．38±29．14） pg／ml，（121．85±16．34） pg／ml vs．（90．45±11．34） pg／ml， P균＜0．05]。결론곡안선알여무유당배방내위양유조우개선영양상태、면역공능，제고위장도격소함량，종이제고치료효과。
Objective To investigate the effects of glutamine and lactose free formula feeding on premature infants with necrotizing enterocolitis nutritional status , immune function and gastrointestinal hormone .Methods Sixty premature in-fant with necrotizing enterocolitis were enrolled in the study , they were randomly divided into observation group and control group with 30 cases in each group , the observation group received glutamine and lactose free formula feeding , the control group were received glutamine and breastfeeding , children nutrition status , immune function , gastrointestinal hormone were compared between the 2 groups..Results (1) nutritional status:4 weeks after treatment, albumin, preprotein content in the observation group were significantly higher than those of control group [(112.31 ±15.23) g/L vs.(103.19 ±13.75) g/L, (41.48 ±5.61)g/L vs.(32.58 ±4.46) g/L, P <0.05].(2)Immune function:2 weeks after treatment, CD4+T cells ratio and IgA, IgG, IgM in the observation group were significantly higher than those of control group [(38.11 ±3.91)% vs. (32.52 ±4.84)%, (13.14 ±1.45) g/L vs.(10.12 ±0.73) g/L,(2.86 ±0.33) g/L vs.(1.77 ±0.21) g/L,(1.43 ± 0.19) g/L vs.(1.02 ±0.13) g/L, P <0.05];CD8+T cells ratio was significantly lower than that control group [(21.95 ± 3.13)%vs.(27.51 ±3.76)%, P <0.05].(3) Guthormone levels: gastrin and motilin content in the observation group were significantly higher than those of control group [(292.45 ±35.82) pg/ml vs.(231.38 ±29.14) pg/ml,(121.85 ± 16.34) pg/ml vs.(90.45 ±11.34) pg/ml, P <0.05].Conclusion Glutamine and lactose free formula feeding is helpful to improve the nutritional status , immune function , improve the gastrointestinal tract hormone content , and improve therapeu-tic effect.