CAJ | 학술논문

目的：探讨立体定向手术治疗难治性抑郁症患者症状及睡眠质量的变化。方法采用立体定向手术治疗抑郁症患者61例，术前及术后3个月采用汉密尔顿抑郁量表（ HAMD-17）和匹兹堡睡眠质量指数量表（ PSQI ）对患者进行评分，根据临床疗效评价标准和HAMD-17减分率来对患者的疗效进行评估，PSQI评分评估患者睡眠质量的改善情况。结果临床疗效评价结果：患者术后3个月临床恢复5例（8ˇ．19％），显著改善23例（37．70％），改善25例（40．98％），无效8例（13．13％），总有效率86．87％。 HAMD-17减分率疗效评价结果：患者手术3个月后痊愈7例（11．48％），显著进步22例（36．07％），进步24例（39．34％），无效8例（13．11％），总有效率为86．89％。 HAMD-17评分显示各个因子和总分与术前相比均显著降低（ P ＜0．01）。 PSQI评分各个因子和总分较术前均显著减少（ P ＜0．01）。结论立体定向手术治疗难治性抑郁症可有效改善抑郁症状，同时全面提高睡眠质量。
목적：탐토입체정향수술치료난치성억욱증환자증상급수면질량적변화。방법채용입체정향수술치료억욱증환자61례，술전급술후3개월채용한밀이돈억욱량표（ HAMD-17）화필자보수면질량지수량표（ PSQI ）대환자진행평분，근거림상료효평개표준화HAMD-17감분솔래대환자적료효진행평고，PSQI평분평고환자수면질량적개선정황。결과림상료효평개결과：환자술후3개월림상회복5례（8ˇ．19％），현저개선23례（37．70％），개선25례（40．98％），무효8례（13．13％），총유효솔86．87％。 HAMD-17감분솔료효평개결과：환자수술3개월후전유7례（11．48％），현저진보22례（36．07％），진보24례（39．34％），무효8례（13．11％），총유효솔위86．89％。 HAMD-17평분현시각개인자화총분여술전상비균현저강저（ P ＜0．01）。 PSQI평분각개인자화총분교술전균현저감소（ P ＜0．01）。결론입체정향수술치료난치성억욱증가유효개선억욱증상，동시전면제고수면질량。
Objective To investigate the changes of stereotactic operation in treating refractory symptoms and sleep quality of patients with depression .Methods Stereotactic operation for the treatment of depression were performed in 61 ca-ses, Hamilton Depression Scale (HAMD-17) and Pittsburgh sleep quality index (PSQI) score were tested on these patients before operation and 3 months after operation , according to the clinical efficacy evaluation criteria and HAMD-17 score reduc-tion rate to evaluate the curative effect , PSQI score was used to evaluate the situation , improvement of the quality of sleep .Re-sults Clinical evaluation results:after 3 months, 5 patients were clinical recovered (8.19%), significantly improved in 23 cases (37.70%), improved in 25 cases (40.98%), and invalid in 8 cases (13.13%), the total efficiency were 86.87%. HAMD-17 reduction rate of curative effect evaluation results:in the 3 months after operation, 7 cases were cured (11.48%), 22 cases with significant progress (36.07%), progress in 24 cases (39.34%), invalid in 8 cases (13.11%), the total effi-ciency was 86 .89%.HAMD-17 score reveal that all the factors and total score decreased significantly compared with the be -fore operation ( P <0.01).The PSQI score of each factor and total score were significantly lower than that before operation (P <0.01).Conclusion Stereotactic surgery in the treatment of refractory depression can effectively improve the symptoms of depression, and comprehensively improve the quality of sleep .