中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
24期
73-75
,共3页
王晓晖%张书峰%孟庆磊%王旭辉%鲍俊涛%朱林超
王曉暉%張書峰%孟慶磊%王旭輝%鮑俊濤%硃林超
왕효휘%장서봉%맹경뢰%왕욱휘%포준도%주림초
血管瘤%平阳霉素%普萘洛尔
血管瘤%平暘黴素%普萘洛爾
혈관류%평양매소%보내락이
Hemangioma%Pingyangmycin%Propranolol
目的：探讨平阳霉素局部注射与口服普萘洛尔治疗颜面部血管瘤的疗效。方法选择婴幼儿体表增生期血管瘤患儿共156例，分为两组，平阳霉素组75例，采用平阳霉素局部注射治疗，普萘洛尔组81例，采用口服普萘洛尔治疗。两组分别随诊6个月。结果随访1个月，平阳霉素组有效率达26.7%，显著高于普萘洛尔组（6.2%），两组间差异有统计学意义（ P <0.05）；随访6个月，平阳霉素组瘤体减少体积（ ml）、血管密度减少（n/ cm2）、有效率、治愈率分别为（6.3±4.2）ml、（4.0 ± 2.3）n/ cm2、78.6%及70.6%，均显著低于普萘洛尔组的（8.5±3.6）ml、（5.2 ± 2.1）n/ cm2、95.1%及90.1%，两组比较差异有统计学意义（P <0.05），各组均未出现严重并发症。结论平阳霉素作用快，尤其适合体积较小且表浅的血管瘤，口服普萘洛尔治疗婴幼儿头面部增生期血管瘤方法简单、疗效可靠、副作用小，可作为婴幼儿血管瘤增生期的临床一线治疗方法。
目的：探討平暘黴素跼部註射與口服普萘洛爾治療顏麵部血管瘤的療效。方法選擇嬰幼兒體錶增生期血管瘤患兒共156例，分為兩組，平暘黴素組75例，採用平暘黴素跼部註射治療，普萘洛爾組81例，採用口服普萘洛爾治療。兩組分彆隨診6箇月。結果隨訪1箇月，平暘黴素組有效率達26.7%，顯著高于普萘洛爾組（6.2%），兩組間差異有統計學意義（ P <0.05）；隨訪6箇月，平暘黴素組瘤體減少體積（ ml）、血管密度減少（n/ cm2）、有效率、治愈率分彆為（6.3±4.2）ml、（4.0 ± 2.3）n/ cm2、78.6%及70.6%，均顯著低于普萘洛爾組的（8.5±3.6）ml、（5.2 ± 2.1）n/ cm2、95.1%及90.1%，兩組比較差異有統計學意義（P <0.05），各組均未齣現嚴重併髮癥。結論平暘黴素作用快，尤其適閤體積較小且錶淺的血管瘤，口服普萘洛爾治療嬰幼兒頭麵部增生期血管瘤方法簡單、療效可靠、副作用小，可作為嬰幼兒血管瘤增生期的臨床一線治療方法。
목적：탐토평양매소국부주사여구복보내락이치료안면부혈관류적료효。방법선택영유인체표증생기혈관류환인공156례，분위량조，평양매소조75례，채용평양매소국부주사치료，보내락이조81례，채용구복보내락이치료。량조분별수진6개월。결과수방1개월，평양매소조유효솔체26.7%，현저고우보내락이조（6.2%），량조간차이유통계학의의（ P <0.05）；수방6개월，평양매소조류체감소체적（ ml）、혈관밀도감소（n/ cm2）、유효솔、치유솔분별위（6.3±4.2）ml、（4.0 ± 2.3）n/ cm2、78.6%급70.6%，균현저저우보내락이조적（8.5±3.6）ml、（5.2 ± 2.1）n/ cm2、95.1%급90.1%，량조비교차이유통계학의의（P <0.05），각조균미출현엄중병발증。결론평양매소작용쾌，우기괄합체적교소차표천적혈관류，구복보내락이치료영유인두면부증생기혈관류방법간단、료효가고、부작용소，가작위영유인혈관류증생기적림상일선치료방법。
Objective To investigate the effects of Pingyangmycin local injection and oral prop-ranolol on infantile hemangiomas. Methods One hundred and fifty-six infants with body surface pro-liferative hemangiomas were selected,and devided into two groups,Pingyangmycin group( 75 ca-ses),who were given Pingyangmycin local injection therapy,Propranolol group(81 cases),who were given oral Propranolol. The two groups were followed up for 6 months. Results Follow-up for one month,the effective rate of BLM Group was 26. 7% ,which was significantly higher than that of the propranolol group( 6. 2% ),the difference between the two groups was statistically significant ( P < 0. 05);follow-up for 6-month,in BLM group the tumor reduced volume( ml),reduced vessel density( n / cm2 ),efficient,the cure rates were(6. 3 ± 4. 2)ml,(4. 0 ± 2. 3)n / cm2 ,78. 6% and 70. 6% ,significantly lower than the those of the Propranolol group[( 8. 5 ± 3. 6 )ml, (5. 2 ± 2. 1)n / cm2 ,95. 1% and 90. 1% ]. The difference between the two groups was statistically significant( P < 0. 05),in each group were no severe complications. Conclusions The therapeutic effect of Pingyangmycin is faster,especially for smaller superficial hemangioma,oral Prop-ranolol treatment of proliferative phase of the head and face of infant hemangioma method is simple,effec-tive and reliable,has fewer side effects,so it can be used as the clinical first-line treatment of the prolif-erative phase of infantile hemangioma.
