CAJ | 학술논문

目的：检测急性胰腺炎（AP）患者血清中白细胞介素-1（IL-1）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平，探讨其在病情观察和预后评估中的作用。方法：选取发病时间小于24小时的AP患者58例，分为轻症急性胰腺炎（MAP）组39例，重症急性胰腺炎（SAP）19例两组，于入院第1天、3天、7天检测患者血清中IL-1、IL-6、TNF-α水平。结果：SAP组血清中IL-1、IL-6、TNF-α水平明显高于同期MAP组，差异具有统计学意义（P<0.01）。SAP组第3天比第1天IL-1、IL-6、TNF-α水平略有升高，但差异无统计学意义（P>0.05），第7天IL-1、IL-6、TNF-α水平与同组前两次检测相比较明显下降，差异具有统计学意义（P<0.01），但仍明显高于同期MAP组和对照组。MAP组入院第1天、3天、7天IL-1、IL-6、TNF-α水平逐步下降，差异具有统计学意义（P<0.01），第7天基本恢复正常。与对照组比较无明显差异（P>0.05）。结论：检测AP患者血清中IL-1、IL-6、TNF-α水平有助于评估病情，观测预后。
목적：검측급성이선염（AP）환자혈청중백세포개소-1（IL-1）、백세포개소-6（IL-6）、종류배사인자-α（TNF-α）수평，탐토기재병정관찰화예후평고중적작용。방법：선취발병시간소우24소시적AP환자58례，분위경증급성이선염（MAP）조39례，중증급성이선염（SAP）19례량조，우입원제1천、3천、7천검측환자혈청중IL-1、IL-6、TNF-α수평。결과：SAP조혈청중IL-1、IL-6、TNF-α수평명현고우동기MAP조，차이구유통계학의의（P<0.01）。SAP조제3천비제1천IL-1、IL-6、TNF-α수평략유승고，단차이무통계학의의（P>0.05），제7천IL-1、IL-6、TNF-α수평여동조전량차검측상비교명현하강，차이구유통계학의의（P<0.01），단잉명현고우동기MAP조화대조조。MAP조입원제1천、3천、7천IL-1、IL-6、TNF-α수평축보하강，차이구유통계학의의（P<0.01），제7천기본회복정상。여대조조비교무명현차이（P>0.05）。결론：검측AP환자혈청중IL-1、IL-6、TNF-α수평유조우평고병정，관측예후。
Objective:To investigate the levels of interleukin-1(IL-1), interleukin-6 (IL-6) and tumor necrosis fac-tor-α (TNF-α) in serum, and discuss their application for disease observation and prognostic assessment of acute pancre-atitis(AP). Methods:Fifty eight patients were selected according to the course of disease in 24 hours, who were divided in-to the mild acute pancreatitis(MAP) group(39 cases) and the severe acute pancreatitis (SAP) group (19 cases). The levels of serum TNF-α, IL-1 and IL-6 were detected at 1, 3 and 7 days of admission. Results:The levels of TNF-α, IL-1 and IL-6 were significantly higher in the SAP group than those in the MAP group (P<0.01). In the SAP group,the concentrations of TNF-α, IL-1 and IL-6 rose slightly on 3rd days, but there were no statistical differences (P>0.05). However, TNF-α, IL-1 and IL-6 levels on 7th days were significantly decreased and were significanty different from the levels on 1st and 3rd days (P<0.01), but still significantly higher than in the MAP group and the controls. For the MAP group, the levels of TNF-α, IL-1 and had IL-6 levels declined gradually and have significant differences compared with the controls (P<0.01). On 7th days of admission, the concentrations of TNF-α, IL-1 and IL-6 almost returned to the baseline(P>0.05). Conclusions:De-tection of TNF-α, IL-1 and IL-6 levels in serum assists in the disease observation and prognostic assessment of AP.